专家人才库数据----中国科学院上海巴斯德研究所

Principal investigator2016

Name:	Lanfeng WANG	Gender:
Education:
Academic degree:	PhD	Academic title:	PI
Departments:	Structural biology of pathogenic mechanism	Discipline:	Biomedicine
Phone:	021-54923167	E-mail:	lanfwang@ips.ac.cn
Mailing Address:	Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai200031, CHINA

Curriculum vitae:
2001, Bachelor, Veterinary, Shandong Agriculture University 2005, Master, Veterinary, Nanjing Agriculture University 2010, Ph.D., Biochemistry and Molecular Biology, Institute of Biophysics, CAS 2010-2015, Postdoc, University of California, San Diego 2016.07-Present, PI, Institut Pasteur Shanghai, CAS

Research direction:
· The structural basis of the complex between virus proteins and host factors (RNA polymerase II, Transcription factors, et al), which transcriptionally regulate virus replication. (Such as HBV, HIV, et al) · Structural analysis to identify key interfaces, active sites and design high specific inhibitors or antibodies to prevent or cure certain diseases.

Research progress:
1. Zhou, H., Wang, F., Wang, H., Chen, C., Zhang, T., Han, X., Wang, L. , Yang, H. (2017). The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget, 8(9), 14830–14834. (, Co-Corresponding Author) 2. Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D., and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author) 3. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015). 4. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author) 5. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014) 6. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide- associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

Research progress:

1. Zhou, H., Wang, F., Wang, H., Chen, C., Zhang, T., Han, X., Wang, L. *, Yang, H. * (2017). The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget, 8(9), 14830–14834. (*, Co-Corresponding Author)

2. Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D.*, and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author)

3. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015).

4. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author)

5. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014)

6. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide- associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

Laboratory members:
Yaling He, Lab Manager Zhaoning Wang, Graduate Student Weiwei Wang, PhD Student Qian Li, Graduate Student Jun Zhang, Graduate Student