Name: | Xiao SU | Gender: | |
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Education: |
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Academic degree: | PhD | Academic title: | PI |
Departments: | Unit of Respiratory Infection and Hstopathology | Discipline: | Immunology |
Phone: | 021-54923110 | E-mail: | xsu@ips.ac.cn |
Mailing Address: | 320 Yueyang Road, Shanghai |
Curriculum vitae: |
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2004-2007 UCSF, Postdoctoral Fellow 2000-2004 Fudan University (2000~2002); UCSF (2002~2004) Ph.D. 1988-1991 Medical School of Suzhou University M.S. 1983-1986 Medical College of Henan University M.D. 2012.03- Professor, Principal Investigator, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 2011.07-2012.02 Associate Researcher, Department of Anesthesia, University of California San Francisco 2009.10-2011.06 Assistant Researcher, Cardiovascular Research Institute, University of California San Francisco 2007.11-2009.09 Research Assistant professor, Department of Pharmacology, University of Illinois at Chicago 2004.07-2007.10 Postdoc, Cardiovascular Research Institute, University of California San Francisco 1991.08-2000.08 Resident, Associate Chief Physician, Director of Intensive Care Medicine, Kailuan Hospital, North China Coal Medical University |
Research direction: |
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Neural regulation of influenza virus, EV71 infection and immunity Neural regulation of stem cell mobilization and repair in lung injury following viral and bacterial infections EV71 and Zika virus-induced neural injury |
Research progress: |
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Representative publications(*corresponding author) 1. Gao Z, Su X*. CFTR regulates acute inflammatory responses in macrophages. QJM:An International Journal of Medicine. 2015;108(12):951-8. 2. Wu HY, Li L, Su X*. Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals. Biomed Res Int. 2014; 2014:283525. 3. Yang X, Zhao CQ, Gao ZW, Su X*. A novel regulator of lung inflammation and immunity: pulmonary parasympathetic inflammatory reflex. QJM: An International Journal of Medicine. 2014; 107:789-792. 4. Wu H, Yang J, Su EM, Li L, Zhao CQ, Yang X, Gao ZW, Pan MY, Sun PY, Sun W, Jiang Y, Su X*. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One 2014; 9: e93003. 5. Zhao C, Su EM, Yang X, Gao Z, Li L, Wu H, Jiang Y, Su X*. Important Role of Platelets in Modulating Endotoxin-Induced Lung Inflammation in CFTR-Deficient Mice. PLoS One. 2013; 8:e82683. 6. Su X*, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of Inflammation-resolving Pathways is associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of Metabolic Syndrome. Mol Med. 2013; 18: 1481-90. 7. Su X*. Leading neutrophils to the alveoli: who is the guider? Am J Respir Crit Care Med. 2012; 186:472-3. 8. Su X*, Looney MR, Su H, Lee JW, Song Y, Matthay MA. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011; 60:619-632. 9. Su X*, Matthay MA, Malik AB. Requisite Role of the cholinergic α7 nAChR Pathway in Suppressing Gram-negative Sepsis-induced Acute Lung Inflammatory Injury. J Immunol. 2010; 184(1): 401-410. 10. Su X*, Looney MR, Naveen G, Matthay MA. Receptor for Advanced Glycation End-products (RAGE) is an Indicator of Direct Lung Injury in Models of Experimental Lung Injury. Am J Physiol Lung Cell Mol Physiol. 2009; 297:L1-5. 11. Su X*, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia. J Immunol. 2008; 180:6947-53. 12. Su X*, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the α7 Nicotinic Acetylcholine Receptor Reduces Acid-induced Acute Lung Injury in Mice and Rats. Am J Respir Cell Mol Biol. 2007; 37:186-192. 13. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary Delivery of Bone Marrow Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-induced Acute Lung Injury in Mice. J Immunol. 2007; 179:1855-1863. 14. Matthay MA, Su X. Pulmonary barriers to pneumonia and sepsis. Nature Med. 2007, 13:780-781. 15. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v) beta(6) integrin-dependent TGF-β activation and promotes acute lung injury. J Clin Invest. 2006; 116:1606-1614. 16. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fcγ receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006; 116:1615-23. 17. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. PAR2 activation induces acute lung inflammation by neuropeptide dependent mechanisms. J Immunol. 2005, 175: 2598-2605. |
Laboratory members: |
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Principal Investigator Xiao Su MD, PhD Fudan University(joint training UCSF)Postdoctoral Fellow, UCSF Laboratory manager Cui Yaqiong, MSc, Nanjing Agricultural University (2016) Laboratory assistant Li Ling, MSc, Chinese Academy of Agricultural Sciences Shanghai Institute of Veterinary Medicine (2012) MS-PhD Student 2012-2017 Zhao Caiqi Qingdao University (2012) Huang Juan Shanghai Ocean University (2014) MS Student Fudan University (2015) Wu Yi Xuzhou Medical College (2015) Postdoctoral Fellow Zhou Shuru PhD (Joint training with Guangzhou Women and Children Center) Di Caixia PhD (Joint training with Ruijin Hospital)
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