专家人才库数据----中国科学院上海巴斯德研究所

Principal investigator2016

Name:

Changbin CHEN

Gender:

Education:

Academic degree:

PhD

Academic title:

Departments:

Pathogenic fungal infection and host immunity

Discipline:

Pathogenic fungus

Phone:

021-54923055

E-mail:

cbchen@ips.ac.cn

Mailing Address:

Institut Pasteur of Shanghai, Chinese Academy of Sciences, Life Science Research Building ,320Yueyang Road, Xuhui District, 200031

Curriculum vitae:
07/2013- Principal Investigator, Unit of Pathogenic Fungal Infection and Host Immunity, The Institut Pasteur of Shanghai, Chinese Academy of Sciences 　　07/2011-06/2013 Assistant Specialist, Department of Microbiology & Immunology, The University of California, San Francisco 　　08/1998-08/2004, The University of Nebraska-Lincoln, USA, Ph.D. 　　09/1995-07/1998, Institute of Plant Physiology & Ecology, Shanghai, Chinese Academy of Sciences, M.S. 　　09/1990-07/1995, Shanghai Fudan University, B.S. 　　07/2013- Principal Investigator, Unit of Pathogenic Fungal Infection and Host Immunity, The Institut Pasteur of Chinese Academy of Sciences Shanghai, 　　07/2011-06/2013 Assistant Specialist, Department of Microbiology & Immunology, The University of California, San Francisco 　　01/2010-06/2011 Postdoctoral Fellow, Department of Microbiology & Immunology, The University of California, San Francisco 　　07/2005-12/2010 Postdoctoral Fellow, Department of Biochemistry & Biophysics, The University of California, San Francisco 　　09/2004-06/2005 Research Technologist, Department of Plant Pathology, The University of Nebraska-Lincoln,

Curriculum vitae:

　　07/2013- Principal Investigator, Unit of Pathogenic Fungal Infection and Host Immunity, The Institut Pasteur of Shanghai, Chinese Academy of Sciences

　　07/2011-06/2013 Assistant Specialist, Department of Microbiology & Immunology, The University of California, San Francisco

　　08/1998-08/2004, The University of Nebraska-Lincoln, USA, Ph.D.

　　09/1995-07/1998, Institute of Plant Physiology & Ecology, Shanghai, Chinese Academy of Sciences, M.S.

　　09/1990-07/1995, Shanghai Fudan University, B.S.

　　07/2013- Principal Investigator, Unit of Pathogenic Fungal Infection and Host Immunity, The Institut Pasteur of Chinese Academy of Sciences Shanghai,

　　07/2011-06/2013 Assistant Specialist, Department of Microbiology & Immunology, The University of California, San Francisco

　　01/2010-06/2011 Postdoctoral Fellow, Department of Microbiology & Immunology, The University of California, San Francisco

　　07/2005-12/2010 Postdoctoral Fellow, Department of Biochemistry & Biophysics, The University of California, San Francisco

　　09/2004-06/2005 Research Technologist, Department of Plant Pathology, The University of Nebraska-Lincoln,

Research direction:
Using two model fungal pathogens (Candida albicans and Cryptococcus neoformans), we study interactions between host and fungal pathogens with three specific aims: identify key signals involved in fungal commensal-pathogen transition; iIllustrate novel host anti-fungal immune mechanisms; and unravel genetic networks driving the dynamics of host-pathogen interactions

Research direction:

Using two model fungal pathogens (Candida albicans and Cryptococcus neoformans), we study interactions between host and fungal pathogens with three specific aims: identify key signals involved in fungal commensal-pathogen transition; iIllustrate novel host anti-fungal immune mechanisms; and unravel genetic networks driving the dynamics of host-pathogen interactions

Research progress:
Representative publications 　　　　1. Gao, N., and Chen, C. (2016) Candida Infections: an update on host immune defenses and anti-fungal drugs. IDTM. Review. 　　2. Pande, K., Chen, C. and Noble, S. M. (2013) Passage through the mammalian gut triggers a phenotypic switch required for Candida albicans commensalism. *Nature Genetics.* 45(9):1088-91 　　3. Chen, C. and Noble, S. M. (2012) Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host. *PLOS Pathogens, 8(11): e1002956. 　　4. Chen, C.,Pande, K., French, S. D., Tuch, B. B. and Noble, S. M. (2011) A unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host & Microbe.* 10(2): 118-35. (equal contribution) 　　5. Dumesic, P., Natarajan, P., Chen, C., Drinnenberg, A., Schiller, B., Moresco, J., Thompson, J., Yates, J., Bartel, D., and Madhani H. (2013) Stalled spliceosomes are a signal for RNAimediated genome defense. Cell: 152(5):957-968. 　　6. Liu, O. W., Chun, C. D., Chow, E. D., Chen, C., Madhani, H. D. and Noble, S. M. (2008) Systematic gene deletion and analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell* 135(1): 174-188. 　　7. Chen, C. and Dickman, M. B. (2005) Proline suppresses apoptosis in the fungal pathogen Colletotrichumtrifolii. *PNAS* 102(9): 3459-3464 　　8. Deng Z., Ma S., Zhou H., Zang A., Fang Y., Li T., Shi H., Liu M., Du M., Taylor P., Zhu H., Chen J., Meng G., Li F., Chen C., Zhang Y., Jia X., Lin X., Zhang X., Pearlman E., Li X., Feng G., and Xiao H. (2015) Shp2 mediates C-type lectin receptor-induced Syk activation and anti-fungal Th17 responses. *Nature Immunology.* 16(6):642-52. 　　9. Xie X., Li F., Wang Y., Lin Z., Cheng X., Liu J., Chen C., and Pan L. (2015) Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2. *Autophagy.11(10):1775-89. 　　10. Chen M., Xing Y., Lu A., Fang W., Sun B., Chen C., Liao W., and Meng G. (2015) Internalized Cryptococcus neoformans activates the canonical Caspase-1 and the noncanonical Caspase-8 inflammasomes. J. Immunol.* 195(10):4962-72. 　　11. Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G. (2014) Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome. *Microbes Infect.* 16(10): 845-54. 　　12. Georgette, C., Chen, C., Shih, S., et al., (2011) A site specific acetylation mark on the essential RSC chromatin remodeling complexpromotes resistance to replication stress. *PNAS* 108(26):10620-10625 　　13. Chen, C. and Dickman, M. B. (2005) cAMP blocks MAPK activation and sclerotial development via Rap-1 in a PKA-independent manner in Sclerotiniasclerotiorum. *Molecular Microbiology* 55(1): 299-311. 　　14. Chen, C., and Dickman, M. B. (2004) Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichumtrifolii by distinct signaling pathways. *Molecular Microbiolology51: 1493-1507. 　　15. Chen, C., Ha, Y-S., Min, J-Y., Memmott, S. D., and Dickman, M. B.. (2006) Cdc42 is required for proper growth and development in the fungal pathogen Colletotrichumtrifolii. Eukaryotic Cell* 5(1): 155-166. 　　16. Scheffer, J., Chen, C., Heidrich, P., Dickman, M. B., and Tudzynski, P. (2005) A CDC42 homologue in Clavicepspurpurea is involved in vegetative differentiation and is essential for pathogenicity. *Eukaryotic Cell* 4(7): 1228-1238. 　　17. Chen, C., and Dickman, M. B. (2002) Colletotrichumtrifolii TB3 kinase, a COT1 homolog, is light inducible and becomes localized in the nucleus during hyphal elongation. *Eukaryotic Cell* 1: 626-633. 　　18. Chen, C., Harel, A., Gorovoits, R., Yarden, O., and Dickman, M. B. (2004) MAPK regulation of sclerotial development in Sclerotiniasclerotiorum is linked with pH and cAMP sensing. *Molecular Plant-Microbe Interactions* 17: 404-413. 　　19. Kim, H.J., Chen, C., Kabbage, M. and Dickman, M.B. (2011) Identification and Characterization of Sclerotiniasclerotiorum NADPH Oxidases. *Applied and Environmental Microbiology* 77(21):7721-9. 　　20. Chen, C., Wanduragala, S., Becker, D. F., and Dickman, M. B. (2006) A tomato QM-like protein protects Saccharomyces cerevisiae cells against oxidative stress by regulating intracellular proline levels. *Applied and Environmental Microbiology* 72(6): 4001-6.

Research progress:

Representative publications

　　1. Gao, N., and Chen, C. (2016) Candida Infections: an update on host immune defenses and anti-fungal drugs. IDTM. Review.

　　2. Pande, K., Chen, C. and Noble, S. M. (2013) Passage through the mammalian gut triggers a phenotypic switch required for Candida albicans commensalism. Nature Genetics. 45(9):1088-91

　　3. Chen, C. and Noble, S. M. (2012) Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host. PLOS Pathogens, 8(11): e1002956.

　　4. Chen, C*.,Pande, K*., French, S. D., Tuch, B. B. and Noble, S. M. (2011) A unique iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host & Microbe. 10(2): 118-35. (*equal contribution)

　　5. Dumesic, P., Natarajan, P., Chen, C., Drinnenberg, A., Schiller, B., Moresco, J., Thompson, J., Yates, J., Bartel, D., and Madhani H. (2013) Stalled spliceosomes are a signal for RNAimediated genome defense. Cell: 152(5):957-968.

　　6. Liu, O. W., Chun, C. D., Chow, E. D., Chen, C., Madhani, H. D. and Noble, S. M. (2008) Systematic gene deletion and analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell 135(1): 174-188.

　　7. Chen, C. and Dickman, M. B. (2005) Proline suppresses apoptosis in the fungal pathogen Colletotrichumtrifolii. PNAS 102(9): 3459-3464

　　8. Deng Z., Ma S., Zhou H., Zang A., Fang Y., Li T., Shi H., Liu M., Du M., Taylor P., Zhu H., Chen J., Meng G., Li F., Chen C., Zhang Y., Jia X., Lin X., Zhang X., Pearlman E., Li X., Feng G., and Xiao H. (2015) Shp2 mediates C-type lectin receptor-induced Syk activation and anti-fungal Th17 responses. Nature Immunology. 16(6):642-52.

　　9. Xie X., Li F., Wang Y., Lin Z., Cheng X., Liu J., Chen C., and Pan L. (2015) Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2. Autophagy.11(10):1775-89.

　　10. Chen M., Xing Y., Lu A., Fang W., Sun B., Chen C., Liao W., and Meng G. (2015) Internalized Cryptococcus neoformans activates the canonical Caspase-1 and the noncanonical Caspase-8 inflammasomes. J. Immunol. 195(10):4962-72.

　　11. Guo C, Chen M, Fa Z, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G. (2014) Acapsular Cryptococcus neoformans activates the NLRP3 inflammasome. Microbes Infect. 16(10): 845-54.

　　12. Georgette, C., Chen, C., Shih, S., et al., (2011) A site specific acetylation mark on the essential RSC chromatin remodeling complexpromotes resistance to replication stress. PNAS 108(26):10620-10625

　　13. Chen, C. and Dickman, M. B. (2005) cAMP blocks MAPK activation and sclerotial development via Rap-1 in a PKA-independent manner in Sclerotiniasclerotiorum. Molecular Microbiology 55(1): 299-311.

　　14. Chen, C., and Dickman, M. B. (2004) Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichumtrifolii by distinct signaling pathways. Molecular Microbiolology51: 1493-1507.

　　15. Chen, C., Ha, Y-S., Min, J-Y., Memmott, S. D., and Dickman, M. B.. (2006) Cdc42 is required for proper growth and development in the fungal pathogen Colletotrichumtrifolii. Eukaryotic Cell 5(1): 155-166.

　　16. Scheffer, J., Chen, C., Heidrich, P., Dickman, M. B., and Tudzynski, P. (2005) A CDC42 homologue in Clavicepspurpurea is involved in vegetative differentiation and is essential for pathogenicity. Eukaryotic Cell 4(7): 1228-1238.

　　17. Chen, C., and Dickman, M. B. (2002) Colletotrichumtrifolii TB3 kinase, a COT1 homolog, is light inducible and becomes localized in the nucleus during hyphal elongation. Eukaryotic Cell 1: 626-633.

　　18. Chen, C., Harel, A., Gorovoits, R., Yarden, O., and Dickman, M. B. (2004) MAPK regulation of sclerotial development in Sclerotiniasclerotiorum is linked with pH and cAMP sensing. Molecular Plant-Microbe Interactions 17: 404-413.

　　19. Kim, H.J., Chen, C., Kabbage, M. and Dickman, M.B. (2011) Identification and Characterization of Sclerotiniasclerotiorum NADPH Oxidases. Applied and Environmental Microbiology 77(21):7721-9.

　　20. Chen, C., Wanduragala, S., Becker, D. F., and Dickman, M. B. (2006) A tomato QM-like protein protects Saccharomyces cerevisiae cells against oxidative stress by regulating intracellular proline levels. Applied and Environmental Microbiology 72(6): 4001-6.

Laboratory members:
Changbin Chen, Ph.D., Professor 　　Team members: 　　Research Assistant：Xinhua Huang, Xiaoyu YU 　　Post-doctoral fellow：Ning Gao 　　Ph.D students：Yinhe Mao 　　M.S student:Yongmin He（graduated) 　　Co-supervising M.S students:Xiaoqing Chen (Shanghai University, graduated), Shanshan Li (Shanghai Normal University), Yuan Tian(Shanghai Jiaotong University/Ruijin Hospital), Qi Ni (Shanghai Jiaotong University/Ruijin Hospital), Chen Wang(Shanghai Jiaotong University/Ruijin Hospital),, Yongqin Wu(maternity hospital /Fudan University) M.S-Ph.D students：Yuanyuan Wang, Xianwei Wu

Laboratory members:

　　Changbin Chen, Ph.D., Professor

　　Team members:

　　Research Assistant：Xinhua Huang, Xiaoyu YU

　　Post-doctoral fellow：Ning Gao

　　Ph.D students：Yinhe Mao

　　M.S student:Yongmin He（graduated)

　　Co-supervising M.S students:Xiaoqing Chen (Shanghai University, graduated), Shanshan Li (Shanghai Normal University), Yuan Tian(Shanghai Jiaotong University/Ruijin Hospital), Qi Ni (Shanghai Jiaotong University/Ruijin Hospital), Chen Wang(Shanghai Jiaotong University/Ruijin Hospital),, Yongqin Wu(maternity hospital /Fudan University)

M.S-Ph.D students：Yuanyuan Wang, Xianwei Wu