专家人才库数据----中国科学院上海巴斯德研究所

Principal investigator2016

Name:	Xiaoming ZHANG	Gender:
Education:
Academic degree:	PhD	Academic title:	PI
Departments:	Unit of Innate Defense and Immune Modulation	Discipline:	Immunology
Phone:	021-54923130	E-mail:	xmzhang@ips.ac.cn
Mailing Address:	Life Science Research Building No. 320 Yueyang Road, Xuhui District, 200031

Curriculum vitae:
2004.10-2007.09:　Ph.D., Immunology, Pierre and Marie Curie (Pairs 6) University, France 　　2000.09-2003.07:　M.S., Biochemistry and Molecular Biology, Yangzhou University,China 　　2012.01- Professor, Principal Investigator, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 　　2007.10- 2011.12: Postdoctoral Researcher, Institut Pasteur, France 　　2011, “1000-talents Plan” for young researchers by the General Office of the Central Committee of the Chinese Communist Party

Curriculum vitae:

　　2004.10-2007.09:　Ph.D., Immunology, Pierre and Marie Curie (Pairs 6) University, France

　　2000.09-2003.07:　M.S., Biochemistry and Molecular Biology, Yangzhou University,China

　　2012.01- Professor, Principal Investigator, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

　　2007.10- 2011.12: Postdoctoral Researcher, Institut Pasteur, France

　　2011, “1000-talents Plan” for young researchers by the General Office of the Central Committee of the Chinese Communist Party

Research direction:
Innate Defense and Immune Modulation

Research direction:

Innate Defense and Immune Modulation

Research progress:
Publications：　　1.Dong Z, Gong K, Huang D, Zhu W, Sun W, Zhang Y, Xin P, Shen Y, Wu P, Li J, Zhang XM^, Wei M^Myocardialinfarctionacceleratesglomerularinjury and microalbuminuria in diabetic rats via local hemodynamics and immunity. *Int J Cardiol,2015, 179:397-408. (^: Corresponding author) 　　2. Zhang XM, Mozeleski B, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. *SciTransl Med. 2014, 6(238):238ra72. 　　3. Zhang XM, Casartelli N, Lemoine S, Mozeleski B, Azria E, Le Ray C, Schwartz O, Launay O, Leclerc C, Lo-Man R. Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings. J Infect Dis. 2014, 210(3):424-434. 　　4. Zhang XM. Regulatory functions of innate-like B cells. Cell MolImmunol, 2013, 10(2): 113-121. 　　5. Zhang XM, Lepelley A, Azria A, Lebon P, Rouguet G, Schwartz O, Launay O, Leclerc C and Lo-Man R. Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses. Plos One, 2013, 8(1): e52003. 　　6. Freire T^？, Zhang XM^？, Deriaud E,Ganneau C, Vichier-Guerre S, Azria E, Launay O, Lo-Man R, Bay S, and Leclerc C. GlycosidicTn-based vaccines targetingdermal DC favor germinal center B celldevelopment and potentantibodyresponses in the absence of adjuvant. Blood, 2010, 116(18): 3526-3536. (^？: equal contribution) 　　7. Zhang XM, Majlessi L, Deriaud E,Leclerc C and Lo-Man R. Coactivation of Syk kinase and MyD88 adaptorproteinpathways by bacteriapromotesregulatoryproperties of neutrophils. Immunity, 2009, 31 (5): 761-771. 8. Zhang XM, Deriaud E, Jiao XA, Braun D, Leclerc C and Lo-Man R. Type I interferonsprotectneonatesfrom acute inflammation through IL-10 producing B cells. J Exp Med*, 2007, 204(5): 1107-1118.

Research progress:

　　Publications：

　　1.Dong Z, Gong K, Huang D, Zhu W, Sun W, Zhang Y, Xin P, Shen Y, Wu P, Li J, Zhang XM^*, Wei M^*Myocardialinfarctionacceleratesglomerularinjury and microalbuminuria in diabetic rats via local hemodynamics and immunity. Int J Cardiol,2015, 179:397-408. (^*: Corresponding author)

　　2. Zhang XM, Mozeleski B, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. SciTransl Med. 2014, 6(238):238ra72.

　　3. Zhang XM, Casartelli N, Lemoine S, Mozeleski B, Azria E, Le Ray C, Schwartz O, Launay O, Leclerc C, Lo-Man R. Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings. J Infect Dis. 2014, 210(3):424-434.

　　4. Zhang XM. Regulatory functions of innate-like B cells. Cell MolImmunol, 2013, 10(2): 113-121.

　　5. Zhang XM, Lepelley A, Azria A, Lebon P, Rouguet G, Schwartz O, Launay O, Leclerc C and Lo-Man R. Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses. Plos One, 2013, 8(1): e52003.

　　6. Freire T^？, Zhang XM^？, Deriaud E,Ganneau C, Vichier-Guerre S, Azria E, Launay O, Lo-Man R, Bay S, and Leclerc C. GlycosidicTn-based vaccines targetingdermal DC favor germinal center B celldevelopment and potentantibodyresponses in the absence of adjuvant. Blood, 2010, 116(18): 3526-3536. (^？: equal contribution)

　　7. Zhang XM, Majlessi L, Deriaud E,Leclerc C and Lo-Man R. Coactivation of Syk kinase and MyD88 adaptorproteinpathways by bacteriapromotesregulatoryproperties of neutrophils. Immunity, 2009, 31 (5): 761-771.

8. Zhang XM, Deriaud E, Jiao XA, Braun D, Leclerc C and Lo-Man R. Type I interferonsprotectneonatesfrom acute inflammation through IL-10 producing B cells. J Exp Med, 2007, 204(5): 1107-1118.

Laboratory members: