| Name: | Xiaozhen LIANG | Gender: | |
|---|---|---|---|
| Education: |
|
||
| Academic degree: | PhD | Academic title: | PI |
| Departments: | virus-associated lymphomagenesis | Discipline: | |
| Phone: | 021-54923096 | E-mail: | xzliang@ips.ac.cn |
| Mailing Address: | Life Science Research Building No. 320 Yueyang Road, Xuhui District, 200031 | ||
| Curriculum vitae: |
|---|
|
1995 Bsc. Peking University, Life Science College, Beijing, China 2002 Ph.D. National University of Singapore, Department of Biological Sciences 2002-2005 Visiting Scholar Harvard Medical School 2006-2012 Postdoctoral Fellow Emory University, Emory Vaccine Center 2013-present Principal Investigator |
| Research direction: |
|---|
Understand gammaherpesvirus pathogenesis (EBV and MHV68) and associated lymphomagenesis. Focusing on 1) virus-host interaction; 2) immune control of virus infection and lymphomagenesis. |
| Research progress: |
|---|
|
1.Define the role of CD95-mediated signaling in gammaherpesvirus-associated lymphomagenesis. CD95-mediated apoptotic signaling is involved in T cell immune control of gammaherpesvirus-associated lymphoma growth, whereas CD95-mediated nonapoptotic signaling regulates gammaherpesvirus latency to evade host immune surveillance. 2.Understand the role of IL16 in gammaherpesviral pathogenesis and indentify the function of one unknown gene RIK in viral infection and host immune response. Publications 1.Lingbing Tan, Chaocan Zhang, Julien Dematos, Linlin Kuang, Jae U Jung and Xiaozhen Liang. CD95 signaling inhibits B cell receptor-mediated gammaherpesviral replication in apoptosis-resistant B lymphoma cells. J Virol. 2016 Nov 1;90(21):9782-9796. 2.Zhang Chaocan, Kuang Linlin, Jiang Wang, Chen Guifang, Liang Xiaozhen. Recombinant expression,polyclonal antibody preparation and primary functional study of a new finding protein RIK.[J]Immunological Journal.2016,32(5)：435-440. 3.JIA Ran, LU Lu, LIANG Xiao-zhen, SUN Zhi-wu, TAN Ling-bing, XU Meng-hua, SU Li-yun, XU Jin..Establishment and analysis of murine model of RSV vaccine-enhanced disease. Journal of Microbes and Infections.2016;11(3):144-52. Patent: Honokiol inhibits herpesvirus infection. 201610343476.4 |
| Laboratory members: |
|---|
Principal Investigator: Xiaozhen Liang Research assistant: Zhongshun Liu Administrative staff: Linlin Kuang M.S-Ph.D. students: Liu wang, Jie Li, Shuai Liu,Long Li, Xingchen Zhou Co-educated M.S-Ph.D. students: Sihan Dong,Ying Gao,Ran Jia |