专家人才库数据----中国科学院上海巴斯德研究所

Principal investigator2016

Name:	Hui XIAO	Gender:
Education:
Academic degree:	PhD	Academic title:	principal investigator
Departments:	Immune Signaling and Regulation	Discipline:	Immunology
Phone:	021-54923127	E-mail:	huixiao@ips.ac.cn
Mailing Address:	320 Yueyang Road, The New Life Science Research Building B,Shanghai, China 200031

Curriculum vitae:
Education: 1997: Ph.D., Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, China. 1991: B.S., School of Life Sciences, Wuhan University, Wuhan, China Academic appointments: 2010-Present: Professor and Principal Investigator, Institut Pasteur of Shanghai 　　 Chinese Academy of Sciences, Shanghai, China 2005-2009: Project Staff, Dept. of Immunology, Cleveland Clinic Foundation, 　　 Cleveland, OH, U.S.A. 1999-2004: Postdoctoral Fellow, Ireland Cancer Center, Case Western Reserve University 　　 Cleveland, OH, U.S.A.

Curriculum vitae:

Education:

1997: Ph.D., Shanghai Institute of Plant Physiology, Chinese Academy of Sciences, China.

1991: B.S., School of Life Sciences, Wuhan University, Wuhan, China

Academic appointments:

2010-Present: Professor and Principal Investigator, Institut Pasteur of Shanghai

　　 Chinese Academy of Sciences, Shanghai, China

2005-2009: Project Staff, Dept. of Immunology, Cleveland Clinic Foundation,

　　 Cleveland, OH, U.S.A.

1999-2004: Postdoctoral Fellow, Ireland Cancer Center, Case Western Reserve University

　　 Cleveland, OH, U.S.A.

Research direction:
The major goal of our research is to decipher the signaling mechanisms by which the pattern-recognition receptors (PRRs, such as TLRs, CLRs, RLR and cGAS/STING) induce the expression of cytokines (including IL-12, IL-10, and IL-23) and IFN-a/b, reprogram cell metabolism, and coordinate cell death/survival. To delineate the molecular and cellular mechanisms underlying the innate immune regulation of T cell responses to microbes and cancers, we aim to study the complex interactions between PRRs and metabolic pathways in the host immune system, focusing on epithelium, macrophages/DCs and T cells, whereby understanding how the innate immune system manages to coordinate the adequate innate and adaptive immune responses to combat pathogens and cancer while tolerate commensals.

Research direction:

The major goal of our research is to decipher the signaling mechanisms by which the pattern-recognition receptors (PRRs, such as TLRs, CLRs, RLR and cGAS/STING) induce the expression of cytokines (including IL-12, IL-10, and IL-23) and IFN-a/b, reprogram cell metabolism, and coordinate cell death/survival. To delineate the molecular and cellular mechanisms underlying the innate immune regulation of T cell responses to microbes and cancers, we aim to study the complex interactions between PRRs and metabolic pathways in the host immune system, focusing on epithelium, macrophages/DCs and T cells, whereby understanding how the innate immune system manages to coordinate the adequate innate and adaptive immune responses to combat pathogens and cancer while tolerate commensals.

Research progress:
1. Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z, Jentsch TJ, Xiao H. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19; 52: 767-781. Corresponding author. 2. Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H, Xiao H. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest. 2020 Apr 1;130(4):2111-2128. Corresponding author. 3. Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q, Yang J, Xiao H. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21;17(8): e3000420. Corresponding author. 4. Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H, Chen J. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nat Commun. 2019, Mar 4;10(1):1015. Corresponding author. 5. Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y. MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018, Mar 28;9(1):1243. 6. Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H. Epigenetic regulator CXXC5 recruit DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017, 214(5):1471-1491. Corresponding author. 7. Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun. 2017, 8(1):959. 8. Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016, 64(2):425-438. 9. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015, 16:642-652. Corresponding author. 10. Du M, Liu J, Chen X, Xie Y, Yuan C, Xiang Y, Sun B, Lan K, Chen M, James SJ, Zhang Y, Zhong J, Xiao H. Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection. J Immunol. 2015, 194:4477-4488. Corresponding author. 11. He L, Zang A, Du M, Ma D, Yuan C, Zhou C, Mu J, Shi H, Li D, Huang H, Deng Q, Xiao J, Yan H, Hui L, Lan K, Xiong S, Li X, Huang Z, Xiao H. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virologica Sinica. 2015, 30:1-16. Corresponding author. 12. Yang C, Guo L, Liu J, Yang J, Zhu K, Xiao H, Leng Q. (2015) Non-Classical MHC I-E negatively regulates macrophage activation and Th17 cells in NOD mice. Sci Rep. 5:12941-12949. Co-corresponding authors. 13. James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015, pii: S2211-1247(15)00176-X. 14. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K. (2015) Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. J Virol. 89:415-427.

Research progress:

1. Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z*, Jentsch TJ*, Xiao H*. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19; 52: 767-781. *Corresponding author.

2. Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H, Xiao H*. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest. 2020 Apr 1;130(4):2111-2128. *Corresponding author.

3. Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q*, Yang J*, Xiao H*. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21;17(8): e3000420. *Corresponding author.

4. Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H*, Chen J*. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nat Commun. 2019, Mar 4;10(1):1015. *Corresponding author.

5. Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y. MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018, Mar 28;9(1):1243.

6. Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H*. Epigenetic regulator CXXC5 recruit DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017, 214(5):1471-1491. *Corresponding author.

7. Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun. 2017, 8(1):959.

8. Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016, 64(2):425-438.

9. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015, 16:642-652. *Corresponding author.

10. Du M, Liu J, Chen X, Xie Y, Yuan C, Xiang Y, Sun B, Lan K, Chen M, James SJ, Zhang Y, Zhong J, Xiao H*. Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection. J Immunol. 2015, 194:4477-4488. *Corresponding author.

11. He L, Zang A, Du M, Ma D, Yuan C, Zhou C, Mu J, Shi H, Li D, Huang H, Deng Q, Xiao J, Yan H, Hui L, Lan K, Xiong S, Li X, Huang Z, Xiao H*. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virologica Sinica. 2015, 30:1-16. *Corresponding author.

12. Yang C, Guo L, Liu J, Yang J, Zhu K, Xiao H*, Leng Q*. (2015) Non-Classical MHC I-E negatively regulates macrophage activation and Th17 cells in NOD mice. Sci Rep. 5:12941-12949. *Co-corresponding authors.

13. James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015, pii: S2211-1247(15)00176-X.

14. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K. (2015) Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. J Virol. 89:415-427.

Laboratory members:
Research Assistant: Jing WEN Postdoctoral fellow: Zhengyan LIANG, Yadong XIE Ph.D students：Xia CHEN, Wei LI, Limin CAO, Li WANG, Nan HU, Yifan ZHAO, Zhugui SHAO M.S students: Haojun MENG, Yanxiang HU, Jinqiu Ding, Sule Yuan