专家人才库数据----中国科学院上海巴斯德研究所

Principal investigator2016

Name:	Lei Pan	Gender:	男
Education:	2010Ph.D., Cell Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 2006-2009 CAS-Stowers joint Ph.D. training programs, Stowers Institute for MedicalResearch, Kansas City, Missouri, US 2004 B.S., the College of Life Sciences, Nankai University, Tianjin, China
Academic degree:	Ph.D.	Academic title:	PI
Departments:	Intestinalmicroenvironmentandhealth	Discipline:	Immunogenetics
Phone:	021-54923090	E-mail:	panlei@ips.ac.cn
Mailing Address:	Life Science Building, Tower A-0320, 320 Yue-yang Road, Shanghai

Curriculum vitae:
2018-present Principal Investigator,The Key Laboratory of Molecular Virology andImmunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences 2014-2018 Professor, The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences 2010-2014 Associate Professor, The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences

Curriculum vitae:

2018-present Principal Investigator,The Key Laboratory of Molecular Virology andImmunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences

2014-2018 Professor, The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences

2010-2014 Associate Professor, The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences

Research direction:
Combing the manipulation of Drosophila and the mouse, at present our lab mainly focus on the regulation of intestinal eco-immunological homeostasis including three aims: 1) Innate immune signaling homeostasis: to identify new regulatory factors and to determine network regulations of mucosal innate immunity, especially to decipher the inter-organ communications to coordinate local-systemic immune signal transduction; 2) Cellular homeostasis: to study the damages initiation and stem cell mediated tissue repair of intestinal epithelia during combating pathogens; 3) Commensal flora homeostasis: to learn corporately the changepattern and the immunological regulation mechanisms of gut commensal microflora and the fat/energy metabolism.

Research direction:

Combing the manipulation of Drosophila and the mouse, at present our lab mainly focus on the regulation of intestinal eco-immunological homeostasis including three aims: 1) Innate immune signaling homeostasis: to identify new regulatory factors and to determine network regulations of mucosal innate immunity, especially to decipher the inter-organ communications to coordinate local-systemic immune signal transduction; 2) Cellular homeostasis: to study the damages initiation and stem cell mediated tissue repair of intestinal epithelia during combating pathogens; 3) Commensal flora homeostasis: to learn corporately the changepattern and the immunological regulation mechanisms of gut commensal microflora and the fat/energy metabolism.

Research progress:
Xiaomeng He, Junjing Yu, Min Wang, Yang Cheng, Yanan Han, Shuo Yang, Lei Sun, Ying Fang, Si-tang Gong, Zhong Wang, Yang-Xin Fu, Lei Pan^# and Hong Tang^#. Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice. *Nature Microbiology,2, 17056 (2017). (#Correspondence author) Pan L, Wang S, Lu T, Weng C, Song X, Park J, Sun J, Yang Z, Yu J, Tang H, McKearin D, Chamovitz D, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. NATURE, 2014; doi:10.1038/nature13562 Yan D, Neumuller RA, Buckner M, Ayers K, Li H, Hu Y, Yang ZD, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, and Perrimon N. A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal. Developmental Cell* 2014, 28, 459–473. (Resource article) Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, Pan Y, Du J, Guo M, Cao H, Chen H, Wang Z, Pei R, Wang Q, Pan L, Niu J, Chen X, Tang H. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice.Cell Research,2014;doi:10.1038 Yu J, He X, Chen Y, Hao Y, Yang S, Wang L, Pan L^#and Tang H^#. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. *J BIOL CHEM* 2013, 288 (1): 79-88 (#Correspondence author) Zhang X, Weng C, Li Y, Wang X, Jiang C, Li X, Xu Y, Chen Q, Pan L^# and Tang H^#.Human Bop is a novel BH3-only member of the Bcl-2 protein family. *ProteinCell* 2012, 3 (10): 790–801(#Correspondence author) Wang X, Pan L, Wang S, Zhou J, Tang H, Xie T. Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. *Plos Genetics* 2011, 7(12): e1002426 (co-first author) Yu J, Pan L, Qin X, Chen H, Xu Y, Chen Y, Tang H. MTMR4 attenuates TGFβ signaling by dephosphorylating R-Smads in endosomes. J Biol Chem. 2010 Mar 12;285(11):8454-62. (Co-first Author) Xie T^#, Song X, Jin Z, Pan L, Weng C, Chen S, Zhang N. Interactions between Stem Cells and Their Niche in the Drosophila Ovary. *Cold Spring HarbSympQuant Biol2008;73, 39-47. (Annual review)* Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. *Cell Stem Cell. 2007;1:458-469. （Faculty 1000 factor=6, cited 105）*

Research progress:

Xiaomeng He*, Junjing Yu*, Min Wang, Yang Cheng, Yanan Han, Shuo Yang, Lei Sun, Ying Fang, Si-tang Gong, Zhong Wang, Yang-Xin Fu, Lei Pan^# and Hong Tang^#. Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice. Nature Microbiology,2, 17056 (2017). (#Correspondence author)

Pan L*, Wang S*, Lu T, Weng C, Song X, Park J, Sun J, Yang Z, Yu J, Tang H, McKearin D, Chamovitz D, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. NATURE, 2014; doi:10.1038/nature13562

Yan D, Neumuller RA, Buckner M, Ayers K, Li H, Hu Y, Yang ZD, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, and Perrimon N. A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal. Developmental Cell 2014, 28, 459–473. (Resource article)

Chen J*, Zhao Y*, Zhang C*, Chen H*, Feng J, Chi X, Pan Y, Du J, Guo M, Cao H, Chen H, Wang Z, Pei R, Wang Q, Pan L, Niu J, Chen X, Tang H. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice.Cell Research,2014;doi:10.1038

Yu J*, He X*, Chen Y, Hao Y, Yang S, Wang L, Pan L^#and Tang H^#. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. J BIOL CHEM 2013, 288 (1): 79-88 (#Correspondence author)

Zhang X, Weng C, Li Y, Wang X, Jiang C, Li X, Xu Y, Chen Q, Pan L^# and Tang H^#.Human Bop is a novel BH3-only member of the Bcl-2 protein family. ProteinCell 2012, 3 (10): 790–801(#Correspondence author)

Wang X*, Pan L*, Wang S, Zhou J, Tang H, Xie T. Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. Plos Genetics 2011, 7(12): e1002426 (co-first author)

Yu J*, Pan L*, Qin X, Chen H, Xu Y, Chen Y, Tang H. MTMR4 attenuates TGFβ signaling by dephosphorylating R-Smads in endosomes. J Biol Chem. 2010 Mar 12;285(11):8454-62. (Co-first Author)

Xie T^#, Song X, Jin Z, Pan L, Weng C, Chen S, Zhang N. Interactions between Stem Cells and Their Niche in the Drosophila Ovary. Cold Spring HarbSympQuant Biol2008;73, 39-47. (Annual review)

Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. Cell Stem Cell. 2007;1:458-469. （Faculty 1000 factor=6, cited 105）

Laboratory members:
Senior lab master: Ms. Zhiqin Fan Research assistant: Dr. Shuo Yang PhD student: Lei Wang Former student: