Name: | Richard LO-MAN | Gender: | |
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Education: | |||
Academic degree: | Ph.D. | Academic title: | Principal Investigator |
Departments: | Immunity and pediatric infectious diseases | Discipline: | Immunology |
Phone: | 86-150 2183 1650 | E-mail: | richard.loman@ips.ac.cn |
Mailing Address: | B409, Life Science Research Building, No.320 Yueyang Road, Xuhui District, 200031 |
Curriculum vitae: |
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2019-present, Professor, Principal investigator, Institut Pasteur of Shanghai, CAS 2016-2018, Research director, Institut Pasteur, Paris, France 2009-2016, Laboratory chief, Institut Pasteur, Paris, France |
Research direction: |
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Research progress: |
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Achievements - Development of a therapeutic cancer vaccine up to phase I clinical trial - 1st evidence of fetal Breg development and characterization of a biomarker of RSV induced bronchiolitis in newborns. - 1st demonstration of the capacity of newborn moDC to induce neonatal TH1 reponses. Demonstration of an alternative pathway for new adjuvant design for pediatric vaccination. - 1st evidence of fetal development of memory T cell in humans. - 1st evidence of regulatory of neutrophils. Demonstration provided in the context of TB infection. - Demonstration that IFNI-IL10 crosstalk suppresses neonatal lethal inflammation. - 1st evidence of regulatory B cells in a neonatal setting. 1. Zhivaki D, Lo-Man R. T cell memory in utero. Seminars in Immunpathology. 2017;39(6):585-592.(IF=6.5) 2. Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Herve PL, Deriaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eleouet JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissieres P, Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity. 2017;46(2):301-314. (IF 21.5) 3. Zhang X, Zhivaki D, Lo-Man R. Unique aspects of the perinatal immune system. Nature reviews Immunology. 2017;17(8):495-507. (IF=42) 4. Lemoine S, Jaron B, Tabka S, Ettreiki C, Deriaud E, Zhivaki D, Le Ray C, Launay O, Majlessi L, Tissieres P, Leclerc C, Lo-Man R. Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells. The Journal of allergy and clinical immunology. 2015;136(5):1355-1368 e1315. (IF=14) 5. Zhang X, Mozeleski B, Lemoine S, Deriaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med. 2014;6(238):238ra272. (IF=17)
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Laboratory members: |
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Positions available (Students, Technicians, Research assistant or Postdoc). |