专家人才库数据----中国科学院上海巴斯德研究所

Principal investigator2016

Name:	Parag KUNDU	Gender:
Education:	PhD IICB Kolkata, Cell biology and signaling, India.(2009)
Academic degree:	Ph.D	Academic title:	Principal Investigator
Departments:	Microbiota-Host Interactions	Discipline:	Stem cell biology and microbiology
Phone:	86-21-54923083	E-mail:	parag.kundu@ips.ac.cn
Mailing Address:	B801, Life Science Research Building, 320 Yueyang Road, Xuhui District, 200031.

Curriculum vitae:
2019-till date: Principal Investigator at Institute Pasteur Shanghai, Chinese Academy of Sciences. 2011-2019: Senior Research Fellow at SCELSE/LKC Medicine, NTU Singapore. April-June, 2016: Visiting Scientist at Pasteur Institute, France. 2009-2011: Post-doctoral fellow at Karolinska Institute, Sweden.

Curriculum vitae:

2019-till date: Principal Investigator at Institute Pasteur Shanghai, Chinese Academy of Sciences.

2011-2019: Senior Research Fellow at SCELSE/LKC Medicine, NTU Singapore.

April-June, 2016: Visiting Scientist at Pasteur Institute, France.

2009-2011: Post-doctoral fellow at Karolinska Institute, Sweden.

Research direction:
The gut microbiota seems to play a crucial role in maintaining host physiology by integrating signals from environmental factors such as diet, xenobiotics, temperature, stress and host-intrinsic cues like ageing. Undesirable changes in the gut microbiota composition (dysbiosis), while responding to innate or environmental stressors have been implicated as a critical determinant in the development of various modern diseases. Our prime interest is to understand the evolving gut microbiota-host relations during distinct milestones across the lifespan of a host with special focus on intestinal epithelium that serves as a platform mediating this crosstalk. In particular, we study the influence of symbiotic or dysbiotic microbial signatures on intestinal stem cells, which maintain the epithelial dynamics and functions of the gut. Our goal is to decipher the molecular mechanisms through which gut microbiota influences key intestinal stem cell signaling pathways and functions during homeostasis or dysbiosis across host age. We are using state-of-the-art systems biology tools such as metagenomics and metabolomics, coupled with hypothesis-driven research in gnotobiotic animal models and human cohorts to elucidate the mechanistic aspects of microbiota-host communications. Our ultimate objective is to develop novel innovative therapeutic interventions targeting the gut microbiota against ageing associated human diseases such as cancer.

Research direction:

The gut microbiota seems to play a crucial role in maintaining host physiology by integrating signals from environmental factors such as diet, xenobiotics, temperature, stress and host-intrinsic cues like ageing. Undesirable changes in the gut microbiota composition (dysbiosis), while responding to innate or environmental stressors have been implicated as a critical determinant in the development of various modern diseases. Our prime interest is to understand the evolving gut microbiota-host relations during distinct milestones across the lifespan of a host with special focus on intestinal epithelium that serves as a platform mediating this crosstalk. In particular, we study the influence of symbiotic or dysbiotic microbial signatures on intestinal stem cells, which maintain the epithelial dynamics and functions of the gut. Our goal is to decipher the molecular mechanisms through which gut microbiota influences key intestinal stem cell signaling pathways and functions during homeostasis or dysbiosis across host age. We are using state-of-the-art systems biology tools such as metagenomics and metabolomics, coupled with hypothesis-driven research in gnotobiotic animal models and human cohorts to elucidate the mechanistic aspects of microbiota-host communications. Our ultimate objective is to develop novel innovative therapeutic interventions targeting the gut microbiota against ageing associated human diseases such as cancer.

Research progress:
Selected publications 1. Kundu P, Lee H U, Perez I G, Tay X Y, Kim H, Faylon L E, Ann M K, Purbojati R, Moses D, Ghosh S, Nicholson J K, Schuster S, Holmes E and Pettersson S. Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. Sci Transl Med. Nov 13;11(518). doi: 10.1126/scitranslmed.aau4760 *(2019). Corresponding author. 2. Lahiri S, KimH, PerezI G, Reza M M, Martin K A, KunduP*, Cox L, Selkrig J, PosmaJ M, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser M J, Auwerx J, Holmes E, Nicholson J, Wahli Wand Pettersson S. Microbiome signaling pathways influence skeletal muscle mass and function. Sci Transl Med.* Jul 24;11(502). pii: eaan5662. doi: 10.1126/scitranslmed.aan5662 (2019). 3. Huang Z, Wang J, Xu X, Wang H, Qiao Y, Chu C W, Xu S, Chai L, Cottier F, Pavelka N, Oosting M, Joosten L A.B, Netea M, Ng CYL, Leong K P, Kundu P, Lam K, Pettersson S, Wang Y. Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nat Microbiol. Mar 4. doi: 10.1038/s41564-019-0381-1 (2019). *4. Kundu P^$,,** Blacher E^, Elinav E^$ and Pettersson S^$. “Our gut microbiome: The evolving inner self”. Cell. Dec 14;171(7):1481-1493. doi: 10.1016/j.cell.2017.11.024 (2017). ^$Corresponding authors, ^Equal contribution. 5. Chng S H, Kundu P, Dominguez-Brauer C, Wei Ling T, Kawajiri K, Fujii-Kuriyama Y, Mak T W and Pettersson S. Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity. Sci Rep. 12;6:23820. doi: 10.1038/srep23820 (2016). 6. Kundu P¹, Genander M¹,Str？？t K, Classon J, Ridgway R A, Tan E H, Bj？rk J, Martling A, Es J V, Sansom O J, Clevers H, Pettersson S and Frisén J. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. *Sci Transl Med.* Apr 1;7(281):281ra44. doi: 10.1126/scitranslmed.3010567 (2015). ¹Both authors contributed equally. Highlighted by The Straits Times. http://news.ntu.edu.sg/Pages/NewsDetail.aspx?URL=http://news.ntu.edu.sg/news/Pages/NR2015_Apr02.aspx&Guid=7bfec5e6-ce83-406f-8c41-1d5be6c54ded&Category=News+Releases 7. Kundu P and Pettersson S. Immunology: Mammalian watchdog targets bacteria. *Nature.* Aug 28;512(7515):377-8. doi: 10.1038/nature13741 (2014). 8. Kundu P, Wei Ling T, Korecka A, Li Y, D’Arienzo R, Bunte RM, Berger T, Arulampalam V, Chambon P, Mak T W, Wahli W and Pettersson S. Absence of intestinal PPARg aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway. *Plos Pathogens. 10(1): e1003887. doi:10.1371/journal.ppat.1003887; (2014). 9. Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A,Miklos T, Korecka A,Bakocevic N, Guan N L, Kundu P, Gulyas B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe B T, Diamond B and Pettersson S. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med.* 6:263ra158 (2014).

Research progress:

Selected publications

1. Kundu P*, Lee H U, Perez I G, Tay X Y, Kim H, Faylon L E, Ann M K, Purbojati R, Moses D, Ghosh S, Nicholson J K, Schuster S, Holmes E and Pettersson S*. Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. Sci Transl Med. Nov 13;11(518). doi: 10.1126/scitranslmed.aau4760 (2019). *Corresponding author.

2. Lahiri S, KimH, PerezI G, Reza M M, Martin K A, KunduP, Cox L, Selkrig J, PosmaJ M, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser M J, Auwerx J, Holmes E, Nicholson J, Wahli Wand Pettersson S. Microbiome signaling pathways influence skeletal muscle mass and function. Sci Transl Med. Jul 24;11(502). pii: eaan5662. doi: 10.1126/scitranslmed.aan5662 (2019).

3. Huang Z, Wang J, Xu X, Wang H, Qiao Y, Chu C W, Xu S, Chai L, Cottier F, Pavelka N, Oosting M, Joosten L A.B, Netea M, Ng CYL, Leong K P, Kundu P, Lam K, Pettersson S, Wang Y. Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nat Microbiol. Mar 4. doi: 10.1038/s41564-019-0381-1 (2019).

4. Kundu P^$,*, Blacher E^*, Elinav E^$ and Pettersson S^$. “Our gut microbiome: The evolving inner self”. Cell. Dec 14;171(7):1481-1493. doi: 10.1016/j.cell.2017.11.024 (2017). ^$Corresponding authors, ^*Equal contribution.

5. Chng S H, Kundu P, Dominguez-Brauer C, Wei Ling T, Kawajiri K, Fujii-Kuriyama Y, Mak T W and Pettersson S. Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity. Sci Rep. 12;6:23820. doi: 10.1038/srep23820 (2016).

6. Kundu P¹, Genander M¹,Str？？t K, Classon J, Ridgway R A, Tan E H, Bj？rk J, Martling A, Es J V, Sansom O J, Clevers H, Pettersson S and Frisén J. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Sci Transl Med. Apr 1;7(281):281ra44. doi: 10.1126/scitranslmed.3010567 (2015). ¹Both authors contributed equally. Highlighted by The Straits Times.

http://news.ntu.edu.sg/Pages/NewsDetail.aspx?URL=http://news.ntu.edu.sg/news/Pages/NR2015_Apr02.aspx&Guid=7bfec5e6-ce83-406f-8c41-1d5be6c54ded&Category=News+Releases

7. Kundu P and Pettersson S. Immunology: Mammalian watchdog targets bacteria. Nature. Aug 28;512(7515):377-8. doi: 10.1038/nature13741 (2014).

8. Kundu P, Wei Ling T, Korecka A, Li Y, D’Arienzo R, Bunte RM, Berger T, Arulampalam V, Chambon P, Mak T W, Wahli W and Pettersson S. Absence of intestinal PPARg aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway. Plos Pathogens. 10(1): e1003887. doi:10.1371/journal.ppat.1003887; (2014).

9. Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A,Miklos T, Korecka A,Bakocevic N, Guan N L, Kundu P, Gulyas B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe B T, Diamond B and Pettersson S. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 6:263ra158 (2014).

Laboratory members:
Administrative Assistant: Ashley XING Email: slxing@ips.ac.cn Postdoc: Lisa PENG Email: lhpeng@ips.ac.cn PhD Student: Panpan FENG Email: ppfeng@ips.ac.cn PhD student: Shuning ZHANG Email: snzhang@ips.ac.cn PhD student: Haiyue DANG Email: hydang@ips.ac.cn Research Assistant: Yuchen LI Email: ycli@ips.ac.cn Visiting Scientist: Shyamal Goswami Email: shyamalg@ips.ac.cn

Laboratory members:

Administrative Assistant: Ashley XING
Email: slxing@ips.ac.cn

Postdoc: Lisa PENG

Email: lhpeng@ips.ac.cn

PhD Student: Panpan FENG

Email: ppfeng@ips.ac.cn

PhD student: Shuning ZHANG

Email: snzhang@ips.ac.cn

PhD student: Haiyue DANG

Email: hydang@ips.ac.cn

Research Assistant: Yuchen LI

Email: ycli@ips.ac.cn

Visiting Scientist: Shyamal Goswami

Email: shyamalg@ips.ac.cn