专家人才库数据----中国科学院上海巴斯德研究所

Principal investigator2016

Name:	Bo LIU	Gender:
Education:	2003 B.S., School of Life Sciences, Fudan University, Shanghai, China 2010 Ph.D., Biochemistry and Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
Academic degree:	Ph.D	Academic title:	Principal Investigator
Departments:	Unit of Innate Immunity and Inflammatory Disease	Discipline:	Immunology
Phone:	021-54923105	E-mail:	bliu@ips.ac.cn
Mailing Address:	Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, China

Curriculum vitae:
2020-Present Professor and Principal investigator, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 2017-2020 Associate Specialist, University of California Berkeley, Berkeley, CA, USA 2013-2017 Postdoctoral Scholar, University of California Berkeley, Berkeley, CA, USA 2010-2013 Research Associate, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

Curriculum vitae:

2020-Present Professor and Principal investigator, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

2017-2020 Associate Specialist, University of California Berkeley, Berkeley, CA, USA

2013-2017 Postdoctoral Scholar, University of California Berkeley, Berkeley, CA, USA

2010-2013 Research Associate, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China

Research direction:
Our research lies at the field of innate immune recognition and inflammation. We focus on the molecular mechanisms of nucleic-acid sensing via Toll-like receptors (TLRs) underlying infections, inflammatory diseases, and autoimmunity. We also hope to better understand the modulation of immune cell functions through nucleic acid-sensing signaling during viral infections, as well as develop new strategies in therapeutics of inflammatory diseases.

Research direction:

Our research lies at the field of innate immune recognition and inflammation. We focus on the molecular mechanisms of nucleic-acid sensing via Toll-like receptors (TLRs) underlying infections, inflammatory diseases, and autoimmunity. We also hope to better understand the modulation of immune cell functions through nucleic acid-sensing signaling during viral infections, as well as develop new strategies in therapeutics of inflammatory diseases.

Research progress:
The laboratory focuses on two and intertwined aspects of studies, i.e., immunogenetics and viral immunopathology. Two typical disease model systems. Publications: Lind, N.^#, Rael, V.^#, Pestal, K.^#, Liu, B., and Barton, G. Regulation of nucleic acid-sensing Toll-like receptors. *Nature Reviews Immunology. (In revision) Wang, Z., Fang, Z., Chen, G., Liu, B., Xu, J., Li, F., Li, F., Liu, H., Zhang, H., Sun, Y., Tian, G., Zhang, L., Chen, H., Xu, G., Hu, L., Ji, H. (2021). Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway. Neoplasia* 23(2), 222-233. Majer, O.^#, Liu, B. ^{#, }, Kreuk, L., Krogan, N., and Barton, G^. (2019). Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity. *Nature* 575, 366-370. (^#Contributed equally; ^Corresponding author. Highlighted by Nature Reviews Immunology.) Majer, O., Liu, B., Woo, B., Kreuk, L., Van Dis, E., and Barton, G. (2019). Release from Unc93b1 in endosomes reinforces the compartmentalized activation of select nucleic acid-sensing TLRs. Nature* 575, 371-374. (Highlighted by Nature Reviews Immunology.) Majer, O., Liu, B., and Barton, G. (2017). Nucleic acid-sensing TLRs: trafficking and regulation. *Current Opinion in Immunology* 44, 26-33. Mardaryev, A., Liu, B., Rapisarda, V., Poterlowicz, K., Malashchuk, I., Rudolf, J., Sharov, A., Jahoda, C., Fessing, M., Benitah, S., Xu, G., and Botchkarev, V. (2016). Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. *Journal of Cell Biology* 212(1), 77-89. Liu, B., Liu, Y., Du, Y., Mardaryev, A., Yang, W., Chen, H., Xu, Z., Xu, C., Zhang, X., Botchkarev, V., Zhang, Y., and Xu, G. (2013). Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. *Development* 140, 780-788. ¹Contributed equally. Du, Y., Liu, B., Guo, F., Xu, G., Ding, Y., Liu, Y., Sun X., and Xu, G. (2012). The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. *PLoS ONE* 7, e47358. Liu, B., Lin, Y., Darwanto, A., Song, X., Xu, G., and Zhang, K. (2009). Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. *Journal of Biological Chemistry* 284, 32288-32295.

Research progress:

The laboratory focuses on two and intertwined aspects of studies, i.e., immunogenetics and viral immunopathology. Two typical disease model systems.

Publications:

Lind, N.^#, Rael, V.^#, Pestal, K.^#, Liu, B., and Barton, G. Regulation of nucleic acid-sensing Toll-like receptors. Nature Reviews Immunology. (In revision)

Wang, Z., Fang, Z., Chen, G., Liu, B., Xu, J., Li, F., Li, F., Liu, H., Zhang, H., Sun, Y., Tian, G., Zhang, L., Chen, H., Xu, G., Hu, L., Ji, H. (2021). Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway. Neoplasia 23(2), 222-233.

Majer, O.^#, Liu, B. ^{#, *}, Kreuk, L., Krogan, N., and Barton, G^*. (2019). Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity. Nature 575, 366-370. (^#Contributed equally; ^*Corresponding author. Highlighted by Nature Reviews Immunology.)

Majer, O., Liu, B., Woo, B., Kreuk, L., Van Dis, E., and Barton, G. (2019). Release from Unc93b1 in endosomes reinforces the compartmentalized activation of select nucleic acid-sensing TLRs. Nature 575, 371-374. (Highlighted by Nature Reviews Immunology.)

Majer, O., Liu, B., and Barton, G. (2017). Nucleic acid-sensing TLRs: trafficking and regulation. Current Opinion in Immunology 44, 26-33.

Mardaryev, A., Liu, B., Rapisarda, V., Poterlowicz, K., Malashchuk, I., Rudolf, J., Sharov, A., Jahoda, C., Fessing, M., Benitah, S., Xu, G., and Botchkarev, V. (2016). Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. Journal of Cell Biology 212(1), 77-89.

Liu, B., Liu, Y., Du, Y., Mardaryev, A., Yang, W., Chen, H., Xu, Z., Xu, C., Zhang, X., Botchkarev, V., Zhang, Y., and Xu, G. (2013). Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development 140, 780-788. ¹Contributed equally.

Du, Y., Liu, B., Guo, F., Xu, G., Ding, Y., Liu, Y., Sun X., and Xu, G. (2012). The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS ONE 7, e47358.

Liu, B., Lin, Y., Darwanto, A., Song, X., Xu, G., and Zhang, K. (2009). Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. Journal of Biological Chemistry 284, 32288-32295.

Laboratory members:
Research Assistant：Yaxing NIE We are recruiting.

Laboratory members:

Research Assistant：Yaxing NIE

We are recruiting.