专家人才库数据----中国科学院上海巴斯德研究所

博士生导师

姓名:	王岚峰	性别:	男
学历:	博士
专家类别:	2016上海市东方学者特聘教授；2017上海市“浦江人才”	职称:	研究员
所属部门:	病原微生物致病机制的结构生物学研究组	学科类别:	生物医学
联系电话:	021-54923167	电子邮箱:	lanfwang@ips.ac.cn
通讯地址:	上海市徐汇区岳阳路320号生命科学实验大楼B座

个人简介：
2001年本科毕业于山东农业大学动物医学专业　　2005年硕士毕业于南京农业大学动物医学专业　　2010年博士毕业于中国科学院生物物理研究所生物化学与分子生物学专业　　2010－2015 美国加州大学圣迭戈分校博士后　　2016.7起任中科院上海巴斯德研究所研究组长、研究员、博士生导师

研究方向：
利用结构生物学、生物化学、及细胞生物学等相关手段研究病原微生物的致病机制，进而开展以结构为基础的靶向药物前体的设计和筛选，为防治相关人类重大疾病提供支持(目前聚焦在HBV，HIV，ZIKA等病毒性疾病)。

科研进展：
1. Zhou, H., Wang, F., Wang, H., Chen, C., Zhang, T., Han, X., Wang, L. , Yang, H. (2017). The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget, 8(9), 14830–14834. (, Co-Corresponding Author) 2. Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D., and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author) 3. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015). 4. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author) 5. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014) 6. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

科研进展：

1. Zhou, H., Wang, F., Wang, H., Chen, C., Zhang, T., Han, X., Wang, L. *, Yang, H. * (2017). The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget, 8(9), 14830–14834. (*, Co-Corresponding Author)

2. Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D.*, and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author)

3. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015).

4. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author)

5. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014)

6. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

实验室成员：
何娅玲，助理研究员王肇宁，硕士研究生王伟伟，博士研究生李茜，硕博研究生张俊，硕博研究生

实验室成员：

何娅玲，助理研究员

王肇宁，硕士研究生

王伟伟，博士研究生

李茜，硕博研究生

张俊，硕博研究生