专家人才库数据----中国科学院上海巴斯德研究所

博士生导师

姓名:	Jean-Marc Collard	性别:	男
学历:
专家类别:		职称:	研究员
所属部门:	实验细菌研究组	学科类别:
联系电话:		电子邮箱:	jean-marc.collard@ips.ac.cn
通讯地址:

个人简介：
- 2020 (October 1st) Invited Professor and Principal investigator, Institut Pasteur Shanghai/Chinese Academy of Science, Shanghai, China. - 2014-2020: Head of the Experimental Bacteriology Unit at Pasteur Institute of Madagascar. - 2013-2014: Crisis manager of the Scientific Institute of Public Health, Brussels, Belgium. - 2008-2013: Head of the Biology Unit at the CERMES, Niamey, Niger. - 2001-2008: Head of the Bacteriology Division of the Scientific Institute of Public Health, Brussels, Belgium. -1989-1993: Post-doctoral position and researcher at the Flemish Institute for Technological Research (VITO), Mol, Belgium. -1989: Ph.D. in Life Sciences, University of Liège, Belgium.

个人简介：

- 2020 (October 1st) Invited Professor and Principal investigator, Institut Pasteur Shanghai/Chinese Academy of Science, Shanghai, China.
- 2014-2020: Head of the Experimental Bacteriology Unit at Pasteur Institute of Madagascar.
- 2013-2014: Crisis manager of the Scientific Institute of Public Health, Brussels, Belgium.
- 2008-2013: Head of the Biology Unit at the CERMES, Niamey, Niger.
- 2001-2008: Head of the Bacteriology Division of the Scientific Institute of Public Health, Brussels, Belgium.
-1989-1993: Post-doctoral position and researcher at the Flemish Institute for Technological Research (VITO), Mol, Belgium.
-1989: Ph.D. in Life Sciences, University of Liège, Belgium.

研究方向：
Research Topic: The objective of this unit is to decipher the establishment of bacterial intestinal microbiota in the neonatal period and in the first 1000 days of life to better understand the constraints, the influence of environmental drivers and the dynamics that prevail in the stepwise construction of the bacterial consortia residing in the gut microbiota. The dynamic of bacterial consortia during dysbiosis and disease states will also be addressed. To achieve these goals, we will use a combination of metataxonomics, single cell analysis and culturomics to deeply interrogate the construction of bacterial consortia and the resulting prokaryote-prokaryote episymbosis. We will work in close collaboration with other units, especially those developing microfluidics, organ-on-chip technologies, germ-free animals and omics. 本课题组的目标是解读新生儿期和出生后1000天内细菌肠道微生物群的建立，以更好地了解驻扎在肠道微生物群中的细菌联合体逐步构建的制约因素、环境驱动因素的影响和动态。微生物菌群的失调和疾病状态也将被解决。为了实现这些目标，拟采用宏分类学、单细胞分析和培养学相结合的方法，深入探究细菌群落的构建和由此产生的原核生物-原核生物共生。本课题组将与其他课题组紧密合作，特别是开发微流控、器官芯片技术、无菌动物和组学相关的课题组。 Selected Bibliography: 1. Rakotondrasoa A, Passet V, Herindrainy P, Garin B, Kermorvant-Duchemin E, Delarocque-Astagneau E, Guillemot D, Huynh BT, Brisse S, Collard JM. Characterization of Klebsiella pneumoniae isolates from a mother-child cohort in Madagascar. J Antimicrob Chemother. 2020 Apr 17:dkaa107. doi: 10.1093/jac/dkaa107. 2. Vonaesch P, Morien E, Andrianonimiadana L, Sanke H, Mbecko JR, Huus K, Naharinananirina T, Godje BP, Nigatoloum SN, Vondo SS, Kandou K, Randremanana R, Rakotondrainipiana M, Mazel F, Djore SG, Gody JC, Finlay BB, Rubbo PA, Parfrey LW, Collard JM, Sansonetti P for the Afribiota Investigators. Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa. Proc Natl Acad Sci U S A. 2018; 115(36):E8489-E8498. 3. Jusot JF, Neill DR, Bangert M, Bricio Moreno L, Gaptia Lawan K, Moussa MM, Everett D, Collard JM, Kadioglu A. Inhaled dust and extreme temperatures are risk factors for bacterial pneumonia and meningitis. JFJ and DRN contributed equally to this work; JMC and AK are co-senior authors. J Allergy Clin Immunol. 2016 Jul 14. pii: S0091-6749(16)30616-9. doi: 10.1016/j.jaci.2016.04.062. 4. Collard JM, Issaka B, Zaneidou M, Hugonnet S, Nicolas P, Taha MK, Greenwood B, Jusot JF. Epidemiology changes in meningococcal meningitis strains in Niger from 2008 to 2011: attempt for an explanation and perspectives for vaccination strategy. BMC Infect Dis. 2013; 13:576. doi: 10.1186/1471-2334-13-576. 5. Collard JM, Place S, Denis O, Rodriguez-Villalobos H, Vrints M, Weill FX, Baucheron S, Cloeckaert A, Struelens M, Bertrand S. Travel-acquired salmonellosis due to Salmonella Kentucky resistant to ciprofloxacin, ceftriaxone and cotrimoxazole and associated with treatment failure. J Antimicrob Chemother 2007, 60(5):1183.

研究方向：

Research Topic:
The objective of this unit is to decipher the establishment of bacterial intestinal microbiota in the neonatal period and in the first 1000 days of life to better understand the constraints, the influence of environmental drivers and the dynamics that prevail in the stepwise construction of the bacterial consortia residing in the gut microbiota. The dynamic of bacterial consortia during dysbiosis and disease states will also be addressed.
To achieve these goals, we will use a combination of metataxonomics, single cell analysis and culturomics to deeply interrogate the construction of bacterial consortia and the resulting prokaryote-prokaryote episymbosis.
We will work in close collaboration with other units, especially those developing microfluidics, organ-on-chip technologies, germ-free animals and omics.

本课题组的目标是解读新生儿期和出生后1000天内细菌肠道微生物群的建立，以更好地了解驻扎在肠道微生物群中的细菌联合体逐步构建的制约因素、环境驱动因素的影响和动态。微生物菌群的失调和疾病状态也将被解决。
为了实现这些目标，拟采用宏分类学、单细胞分析和培养学相结合的方法，深入探究细菌群落的构建和由此产生的原核生物-原核生物共生。
本课题组将与其他课题组紧密合作，特别是开发微流控、器官芯片技术、无菌动物和组学相关的课题组。

Selected Bibliography:
1. Rakotondrasoa A, Passet V, Herindrainy P, Garin B, Kermorvant-Duchemin E, Delarocque-Astagneau E, Guillemot D, Huynh BT, Brisse S, Collard JM. Characterization of Klebsiella pneumoniae isolates from a mother-child cohort in Madagascar. J Antimicrob Chemother. 2020 Apr 17:dkaa107. doi: 10.1093/jac/dkaa107.

2. Vonaesch P, Morien E, Andrianonimiadana L, Sanke H, Mbecko JR, Huus K, Naharinananirina T, Godje BP, Nigatoloum SN, Vondo SS, Kandou K, Randremanana R, Rakotondrainipiana M, Mazel F, Djore SG, Gody JC, Finlay BB, Rubbo PA, Parfrey LW, Collard JM, Sansonetti P for the Afribiota Investigators. Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa. Proc Natl Acad Sci U S A. 2018; 115(36):E8489-E8498.

3. Jusot JF, Neill DR, Bangert M, Bricio Moreno L, Gaptia Lawan K, Moussa MM, Everett D, Collard JM, Kadioglu A. Inhaled dust and extreme temperatures are risk factors for bacterial pneumonia and meningitis. JFJ and DRN contributed equally to this work; JMC and AK are co-senior authors. J Allergy Clin Immunol. 2016 Jul 14. pii: S0091-6749(16)30616-9. doi: 10.1016/j.jaci.2016.04.062.

4. Collard JM, Issaka B, Zaneidou M, Hugonnet S, Nicolas P, Taha MK, Greenwood B, Jusot JF. Epidemiology changes in meningococcal meningitis strains in Niger from 2008 to 2011: attempt for an explanation and perspectives for vaccination strategy. BMC Infect Dis. 2013; 13:576. doi: 10.1186/1471-2334-13-576.

5. Collard JM, Place S, Denis O, Rodriguez-Villalobos H, Vrints M, Weill FX, Baucheron S, Cloeckaert A, Struelens M, Bertrand S. Travel-acquired salmonellosis due to Salmonella Kentucky resistant to ciprofloxacin, ceftriaxone and cotrimoxazole and associated with treatment failure. J Antimicrob Chemother 2007, 60(5):1183.

科研进展：

实验室成员：