孟璐，博士，副研究员，硕士生导师。复旦大学博士,美国Albert Einstein College of Medicine博士后。2018年加入天然防御和免疫调控研究组，参与B细胞在肝癌（hepatocellular carcinoma，HCC）中的功能研究。

My research aims to answer 1) “How does Mycobacterium tuberculosis (Mtb) manage to survive within macrophage cells?” On one hand, I’m trying to identify the functional characteristic of the virulence genes expressed by Mtb bacilli during interaction with macrophages, such as ppe family genes, cpsA. On the other hand, I focus on uncovering host immune responses after Mtb infection including uncover macrophage receptor(s). 2) “The function of tumor infiltrating T or B cells in human cancer”. New liver B cell subset was uncovered via scRNA-seq. Moreover, the lack of effective screening strategies and poor prognoses constitutes an urgent need for the discovery of novel means for early detection and therapy of hepatocellular carcinoma (HCC). Anti-tumor antibodies are one of the safest and efficient therapies available for treatment of cancer patients. However, these antibodies are limited so far to rare antigens and limited types of cancer. In addition to study of the interplay between the immune system and cancer cells, we are developing a screening strategy to detect auto-antibodies derived from cancer patients. This strategy was employed in order to generate a potential “target bank” for testing future cloned antibodies.

代表性论文（Representative paper）：

1）Meng, L#; Tong, J#; Gao, Q; Zhang, X; PPE38 Protein of Mycobacterium tuberculosis Inhibits Macrophage MHC Class I Expression and Dampens CD8+ T Cell Responses, Frontiers in cellular and infection microbiology 2017, 10.3389(fcimb.2017.00068).

2）Meng, L#; Tong, J#; Wang, Q; Niu, C; Gao, Q.; Diverse effects of mycobacterial proline-proline-glutamic acid proteins upon interaction with host macrophages, FEMS Microbiol Lett, 2017, 364(4).

3）Ma, J#; Zheng, B#; Goswami, S#; Meng, L#; Zhang, D; Cao, C; Li, T; Zhu, F; Ma L; Zhang, Z; Zhang, S; Duan, M; Chen, Q; Gao, Q; Zhang, X.; PD1(Hi) CD8(+) cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma , J Immunother Cancer, 2019, 7(1): 0-331.

4）Kan, Y#; Meng, L#; Xie, #L; Liu, L#; Dong, W; Feng, J; Yan, Y; Zhao, C; Peng, G; Wang, D; Lu, M; Yang, C; Niu, C.; Temporal modulation of host aerobic glycolysis determines the outcome of Mycobacterium marinum infection , Fish & Shellfish Immunology, 2020, 96: 78-85.

5）Xu, T; Wang, X; Meng, L; Zhu, M; Wu, J; Xu, Y; Zhang, Y; Zhang, W.; Magnesium Links Starvation-Mediated Antibiotic Persistence to ATP , mSphere, 2020, 5(1).