病原宿主互作的细胞生物学及光学成像
[* First author] [§ corresponding author]
1. Shuangshuang Zhao*, Xuemeng Shi*, Yue Zhang*, Zeyu Wen, Jinping Cai, Wei Gao, Jiayi Xu, Yifei Zheng, Baohua Ji, Yanqin Cui, Kun Shi, Yanjun Liu, Hui Li, Yaming Jiu§, “Myosin-18B promotes mechanosensitive CaMKK2-AMPK-VASP regulation of contractile actin stress fibers”. iScience. 2020 Mar 11;23(4):100975.
2. Yaming Jiu*§, Reena Kumari, Aidan M. Fenix, Niccole Schaible, Xiaonan Liu, Markku Varjosalo, Ramaswamy Krishnan, Dylan T. Burnette and Pekka Lappalainen§ “Myosin-18B promotes the assembly of myosin II stacks to drive maturation of contractile actomyosin bundles”. Current Biology. 2019 Jan 7; 29 (1): 81-92. F1000 recommended as ”New Finding”
3. Yaming Jiu*§, Johan Per?nen, Niccole Schaible, Fang Cheng, John Eriksson, Ramaswamy Krishnan, Pekka Lappalainen§ “Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA”. Journal of Cell Science. 2017 Jan 18; 130(5): 892-902.
4. Yaming Jiu*, Jaakko Lehtim?ki, Sari Tojkander, Fang Cheng, Harri J??linoja, Xiaonan Liu, Markku Varjosalo, John E. Eriksson, Pekka Lappalainen§ “Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers”. Cell Reports. 2015 Jun 16; 11(10):1511-1518. F1000 recommended as ”New Finding”
5. Isabel Weinheimer*, Yaming Jiu*, Minna-Liisa Rajam?ki*, Olli Matilainen, Jukka Kallij?rvi, Wilmer J. Cuellar, Rui Lu, Mart Saarma, Carina I. Holmberg, Jussi J?ntti, Jari Valkonen§ “Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants”. Plos Pathogens. 2015 Mar 6; 11(3):e1004711.
细胞骨架网络对细胞结构和功能起重要作用。微丝调控细胞黏附、运动和分裂;中间丝维持细胞形态、弹韧性并作为信号转导的枢纽。这些骨架和非骨架功能本质是由其组装、动态维持及交互调控共同决定的,例如细胞的运动取决于微丝的组装及与中间丝的互作、细胞分裂取决于微管、细胞的机械感受取决于微丝应力纤维的平衡维持、细胞应激下的完整性取决于中间丝的动态重组等。因此,对细胞骨架进行全面系统研究具有重要的生物学意义。重要的是,感染进程中宿主细胞骨架被病原体操纵和胁迫是其实现感染的必需条件。开展宿主细胞骨架体系调控病原体感染的机制研究,将不仅突破我们对病原体利用宿主细胞骨架促进自身感染策略的认识,也是发现新药靶的重要手段,同时也是我们全面认识细胞骨架病理功能的重要途径。
课题组阐明了(1) myosin-18B、formin、tropomodulin、tropomyosin等重要微丝结合蛋白和应力纤维、片状伪足等主要微丝精细结构的生物学功能;(2) 微丝-中间丝的动态维持和互作机制及应激条件诱发中间丝的高敏感性关键调控;(3) 宿主细胞骨架对病原体感染的调控机制。这三个层次的工作在研究内容和实验方法上相辅相承,共同组成了病原细胞骨架生物学研究体系。