1990.9-1991.6 巴黎第六大学  硕士

1991.9-1995.6 巴黎第六大学  博士

1996.1-2001.12 法国巴斯德研究所  研究助理

2002.1-2008.12 法国巴斯德研究所  Research Scientist

2007.6-2007.7巴黎第六大学  HDR（特许任教资格）

2009.1-2016.5 法国巴斯德研究所  lab chief

2016.5-2018.3 法国巴斯德研究所  scientific director

2019.10-至今 中国科学院上海巴斯德研究所 研究员

论文：

1.Szekely, T…, Lo-Man, R., Leclerc, C., & Taillefumier, C. (2018). Design, Synthesis, and Immunological Evaluation of a Multicomponent Construct Based on a Glycotripeptoid Core Comprising B and T Cell Epitopes and a Toll-like Receptor 7 Agonist That Elicits Potent Immune Responses. J Med Chem, 61(21), 9568–9582. IF=6

2.Sayes, F.…Lo-Man, R, Brossier, F, Sougakoff, W, Bottai, D, Brodin, P, Charneau, P, Brosch, R, Majlessi, L. (2018). Multiplexed Quantitation of Intraphagocyte Mycobacterium tuberculosis Secreted Protein Effectors. Cell Rep, 23(4), 1072–1084. IF=7.8

3.Zhivaki D, Lo-Man R. T cell memory in utero. Seminars in Immunpathology. 2017;39(6):585-592. Corresp Auth IF=6.8

4. Zhivaki D, ..., Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity. 2017;46(2):301-314. Corresp Auth IF=21.5

5. Zhang X, Zhivaki D, Lo-Man R. Unique aspects of the perinatal immune system. Nature reviews Immunology. 2017;17(8):495-507. Corresp Auth IF=44

6. Laubreton D,...Lo-Man R, Leclerc C. The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity. Cancer Immunol Immunother. 2016;65(3):315-325. IF=4.9

7. Ganneau C, ..., Lo-Man R, Bay S. Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate. Organic & biomolecular chemistry. 2016;15(1):114-123.IF=3.5

8. Lemoine S, ..., Lo-Man R. Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells. The Journal of allergy and clinical immunology. 2015;136(5):1355-1368 e1315. Corresp Auth IF=14.1

9. Coelho H, ..., Lo-Man R, Leclerc C, Cabrita EJ, Jimenez-Barbero J, Nishimura S, Garcia-Martin F, Marcelo F. The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR. Journal of the American Chemical Society. 2015;137(39):12438-12441.  IF=14.7

10. Zhang X, ..., Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med. 2014;6(238):238ra272. Corresp Auth IF=17.1

11. Zhang X,..., Lo-Man R. Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings. J Infect Dis. 2014;210(3):424-434. Corresp Auth IF=5

12. Lantier L,..., Lo-Man R, Werts C, Laurent F, Lacroix-Lamande S. Poly(I:C)-Induced Protection of Neonatal Mice Against Intestinal Cryptosporidium parvum Infection Requires an Additional TLR5 Signal Provided by the Gut Flora. J Infect Dis. 2014;209(3):457-467.IF=5

专利

Generation of monoclonal anrtibodies against RSV using regulatory B cells from newborns

R. Lo-Man, H. Mouquet, MA Welti, JF Eleouet, S. Riffault, P. Tissières, X. Zhang

US prov 62-45268 filed 17-02-2017

MAG carbohydrate vaccine comprising the same and use. US 6 676 946

S. Bay, D. Cantacuzène, Leclerc C., R. Lo-Man. (Licensed)

US 6,676,946 ; US 7,696,326, CA2285018, EP989137484

微生物群是构建免疫环境，调控母胎界面和影响胎儿发育的一个重要因素。源自母体微生物群或代谢成分的分子可以通过胎盘到达胎儿，或在婴儿出生后存在于母乳中。微生物群的改变可导致妊娠并发症，如胆囊炎和早产，增加对传染病的易感性。出生后，新生儿的免疫系统需要平衡其炎症特性，以调节微生物群定殖，并建立一个屏障，限制病原体感染的风险。儿童免疫系统和微生物群的共进化塑造了免疫力。因此需要通过探索和定义与微生物群的生态变异相关的儿科疾病的免疫特征或生物标志物，来研究早期生命对感染的易感性。

我们的研究假设基于对新生儿特异性免疫组分的发现。课题设计包括以下几个方面: （1）在分子和单细胞水平上识别来自健康和疾病状态的血液和组织中的新生儿免疫细胞群。（2）研究新生儿免疫细胞的发育和功能以及它们与微生物群之间的关系。（3）免疫细胞群和相关分子作为新生儿炎症性传染病的预后指标进行评估。

我们前期的研究从实验室到临床，集中于人呼吸道合胞病毒引起的新生儿毛细支气管炎研究，这种病毒也是婴幼儿下呼吸道感染的主要诱因，而目前已拓展到肠道疾病的研究。

（Our working hypothesis is based on our discovery of newborn specific immune players.

The emerging rules of this age-associated immune network tuning immune responses delineate new possibilities to immune intervention specifically designed for early life.

Our research aim at

1) the identification at the molecular and single cell levels newborn immune cell population in blood and tissues from healthy and disease states.

2) the study the development and function of newborn immune cells and its relationship with microbiota.

3) the evaluation of immune cell population and related molecular indicators as prognostic markers of neonatal inflammatory infectious diseases.

Our previous research from bench to the bedside in newborn patients suffering of bronchiolitis, induced by the human respiratory syncytial virus, the major cause of lower respiratory tract infections in young infants, and we are currently extending to intestinal diseases.）

2019.10: 上海市千人计划

2020.09：CAS PIFI

不同环境下的儿科免疫学研究为探索人类微生物对儿童健康和疾病的影响提供了合适的免疫学武器。这个研究基于高端技术的使用。

The general purpose of my studies are to fullfill the gaps of knowledge of the immune system during the first 1,000 days of life in the evolving context of the microbial colonization following birth, in order to provide the immunological background of development and infectious diseases in the newborn and the infant.

The study of pediatric immunology in various settings offer an appropriate immunological arms to investigate the impact of human microbiota on child health and disease. This research is based on the use of high-end technologies.

实验室成员(Lab member)

研究助理：龚世杰，王婷，顾琦晟，何紫涵

硕士研究生：Pauline OLOO, Cynthia D BETTER

毕业研究生(Graduate student)

招生信息(admission information)

欢迎具有生物学、免疫学等学科背景的优秀学生加入本团队攻读硕士和博士研究生。

欢迎大学二年级（含）以上同学进入实验室参与有关科研学术工作，或联系毕业设计等。