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Parag Kundu
研究员 | 博士生导师
微生物学
微生物与宿主相互作用研究组
  • +86 021-54923083
  • 上海市岳阳路320号生命科学实验楼B801
  • 微生物与宿主相互作用研究Microbiota-Host Interactions

  • 教育背景Study Expreience

    2003-2009 PhD at Indian Institute of Chemical Biology (IICB), on “Role of matrix metalloproteinases on extracellular matrix remodeling during Helicobacter pylori mediated gastric injury: Effect of curcumin”.

    2000-2002 Master of Science in Microbiology from Bangalore University, Bangalore, India.

     

    工作经历Work Experience

    2019-till date         Principal Investigator          Institute Pasteur Shanghai-CAS

    2011-2019            Senior Scientist            SCELSE/LKCMedicine, Singapore.

    April-June, 2016       Visiting Scientist               Pasteur Institute, France.

    2009-2011           Post-doctoral fellow              Karolinska Institute, Sweden.

    2003-2009             PhD student                            IICB, India.

    2002-2003         Guest Lecturer (Microbiology)    Gurudas College Kolkata, India.

  • Guest Editor in Frontiers in Cell and Developmental Biology.
  • 1. XING Y P, Pettersson S*, Kundu P*. Microbial Metabolites & Intestinal Stem Cells tune Intestinal Homeostasis. *Corresponding authors. Proteomics. Jan 29:e1800419. doi: 10.1002/pmic.201800419  (2020).  PMID: 31994831. Impact Factor (IF): 3.722.

    2. Kundu P*, Lee H U, Perez I G, Tay X Y, Kim H, Faylon L E, Ann M K, Purbojati R, Moses D, Ghosh S, Nicholson J K, Schuster S, Holmes E and Pettersson S*. Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. *Corresponding authors. Sci Transl Med. Nov 13;11(518).  doi:10.1126/scitranslmed.aau4760 (2019). PMID: 31723038. Impact Factor (IF): 17.161.

    3. Lahiri S, Kim H, Perez I G, Reza M M, Martin K A, Kundu P, Cox L, Selkrig J, Posma J M, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser M J, Auwerx J, Holmes E, Nicholson J, Wahli W and Pettersson S. Microbiome signaling pathways influence skeletal muscle mass and function. Sci Transl Med. Jul 24;11(502). pii: eaan5662. doi: 10.1126/scitranslmed.aan5662 (2019). PMID: 31341063. Cited by 5 IF: 17.161.

    4. Huang Z, Wang J, Xu X, Wang H, Qiao Y, Chu C W, Xu S, Chai L, Cottier F, Pavelka N, Oosting M, Joosten L A.B, Netea M, Ng CYL, Leong K P, Kundu P, Lam K, Pettersson S, Wang Y. Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nat Microbiol. Mar 4. doi: 10.1038/s41564-019-0381-1 (2019). PMID: 30833732. Cited by 2, IF: 14.3.

    5. Kundu P$,*, Blacher E*, Elinav E$ and Pettersson S$. “Our gut microbiome: The evolving inner self”. Cell. Dec 14;171(7):1481-1493. doi: 10.1016/j.cell.2017.11.024 (2017). $Corresponding authors, *Equal contribution. PMID: 29245010. Cited by 103, IF: 30.41.

    6. Jurek A1, Genander M1, Kundu P, Catchpole T, He X, Str??t K, Sabelstr?m H, Xu N, Pettersson S, Henkemeyer M and Frisén J. Eph receptor interclass cooperation is required for the regulation of cell proliferation. Exp Cell Res.  Aug 23. pii: S0014-4827(16)30256-7. doi: 10.1016/j.yexcr.2016.08.017 (2016). 1Both authors contributed equally. PMID:27565439. Cited by 4, IF: 3.2.

    7. Chng S H, Kundu P, Dominguez-Brauer C, Wei Ling T, Kawajiri K, Fujii-Kuriyama Y, Mak T W and Pettersson S. Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity. Sci Rep. 12;6:23820. doi: 10.1038/srep23820 (2016). PMID:27068235. Cited by 24, IF: 5.578.

    8. Kundu P1, Genander M1, Str??t K, Classon J, Ridgway R A, Tan E H, Bj?rk J, Martling A, Es J V, Sansom O J, Clevers H, Pettersson S and Frisén J. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Sci Transl Med. Apr 1;7(281):281ra44. doi: 10.1126/scitranslmed.3010567 (2015). 1Both authors contributed equally. PMID:25834110. Cited by 13, IF: 17.161. Highlighted by The Straits Times. http://news.ntu.edu.sg/Pages/NewsDetail.aspx?URL=http://news.ntu.edu.sg/news/Pages/NR2015_Apr02.aspx&Guid=7bfec5e6-ce83-406f-8c41-1d5be6c54ded&Category=News+Releases

    9. Kundu P and Pettersson S. Immunology: Mammalian watchdog targets bacteria. Nature. Aug 28;512(7515):377-8. doi: 10.1038/nature13741 (2014). PMID:25119031. Cited by 4, IF: 41.456.

    10. Kundu P, Wei Ling T, Korecka A, Li Y, D’Arienzo R, Bunte RM, Berger T, Arulampalam V, Chambon P, Mak T W, Wahli W and Pettersson S. Absence of intestinal PPARg aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway.  Plos Pathogens. 10(1): e1003887. doi:10.1371/journal.ppat.1003887; (2014). PMID:24465207. Cited by 18, IF: 8.057.

    11. Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Miklos T, Korecka A, Bakocevic N, Guan N L, Kundu P, Gulyas B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe B T, Diamond B and Pettersson S. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 6:263ra158 (2014). PMID:25411471. Cited by 455, IF: 17.161. 

    12. Li Y, Kundu P, Seow SW, de Matos CT, Aronsson L, Chin KC, Krre K, Pettersson S and Greicius G. Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. Carcinogenesis. Mar 29; 33-6:1231-1238; (2012). PMID:22461519. Cited by 97, IF: 5.334.

    13. Kundu P, De R, Pal I, Mukhopadhyay A. K, Saha D.R and Swarnakar S. Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of Helicobacter pylori infection in cultured cells and mice. PLoS One. Jan 21;6(1):e16306; (2011). PMID:21283694. Cited by 38, IF: 3.234.

    14. De R, Kundu P, Swarnakar S, Ramamurti T, Chowdhury A, Nair G. B and Mukhopadhyay A. K. Antimicrobial activity of curcumin against Indian Helicobacter pylori and also during mice infection. Antimicrob. Agents. Ch. 53:1592–97; (2009). PMID:19204190. Cited by 221, IF: 4.476.

    15. Singh L. P1, Kundu P1, Ganguly K, Mishra A and Swarnakar S. Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. Free. Radic. Biol. Med.  43: 289–99; (2007). 1Both authors contributed equally. PMID:17603938. Cited by 36, IF: 5.736.

    16.  Kundu P, Mukhopadhyay A. K, Patra R, Banerjee A, Berg D. E and Swarnakar S. Cag pathogenicity island independent upregulation of matrix metalloproteinases-9 and -2 secretion and expression in mice by Helicobacter pylori infection. J. Biol. Chem. 281:34651–62; (2006). PMID:16966323. Cited by 46, IF: 4.573.

    17. Ganguly K, Kundu P, Banerjee A, Reiter R. J and Swarnakar S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free. Radic. Biol. Med. 41:911–25; (2006). PMID:16934674. Cited by 69, IF: 5.736.

    18. Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P and Sharma A. V. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J. Biol. Chem. 280:9409–15 (2005). PMID:15615723. Cited by 181, IF: 4.573.

  • At CMDH, the main focus of our research unit is to delineate the complex interplay between gut microbiota and stem cells during ageing and cancer. Our unit’s goal is to develop microbiota-based strategies to promote human health during ageing and provide solutions to ageing-associated diseases.

    We have initiated research aimed at understanding the influence of bacterial outer membrane vesicles (OMVs) on host stem cell functions using intestinal organoids and animal models. In parallel, we are investigating how the evolution of gut microbiota during distinct phases of life in particular, the initial phases of host development and ageing, influence host stem cell signaling and functions. We are actively setting up a state-of-the-art germ-free facility at CMDH-IPS, which will significantly contribute to spearhead functional studies involving the gut microbiota.

  • CAS President’s International Fellowship InitiativePIFI Award) for 2021

    Shanghai Thousand Talent 2020

    Shanghai Everest Talent Program 2019-2022

  • The identification of the gut microbiome as a major regulator of host metabolism, immune and cognitive functions in an age dependent manner is a major break-through that has changed our perception of human health. Undesirable changes in the gut microbiota composition (dysbiosis), while responding to innate or environmental stressors have been implicated as a critical determinant in the development of various modern diseases. Our prime interest is to understand the evolving gut microbiota-host relations during distinct milestones across the lifespan of a host with special focus on intestinal epithelium that serves as a platform mediating this crosstalk. In particular, we study the influence of symbiotic or dysbiotic microbial signatures on intestinal stem cells, which maintain the epithelial dynamics and functions of the gut. Our goal is to decipher the molecular mechanisms through which gut microbiota influences key intestinal cell signaling pathways and functions during homeostasis or dysbiosis across host age. We are using state-of-the-art systems biology tools such as metagenomics and metabolomics, coupled with hypothesis-driven research in gnotobiotic animal models and human cohorts to elucidate the mechanistic aspects of microbiota-host communications. Our ultimate objective is to develop novel innovative therapeutic interventions targeting the gut microbiota against ageing associated human diseases such as cancer.

    肠道菌群以年龄依赖的方式调节宿主代谢、免疫和认知功能,这一重大发现改变了我们对人类健康的认识。先天和环境因素导致的肠道菌群失调被认为是很多现代疾病发生、发展的关键因素。我们的主要研究兴趣是了解在宿主不同生命阶段肠道微生物和宿主的相互作用,尤其关注介导这种相互作用的肠道上皮细胞。已有研究发现肠道干细胞在维持肠道上皮动态和功能方面起着重要作用,因此我们的研究重点在于关注共生或非共生微生物对肠道干细胞的影响。我们的研究目标是破译在宿主不同年龄阶段肠道菌群稳态或失调对肠道干细胞信号通路和功能影响的分子机制。我们将采用最先进的系统生物学工具,如宏基因组学和代谢组学,结合以假设为驱动的无菌动物模型和人类群组研究,来阐明微生物和宿主相互作用的机制。我们的最终目标是开发基于肠道微生物群的治疗干预措施,以对抗与衰老相关的人类疾病,例如癌症等疾病。

     

    实验室成员(Lab member)

    实验室管家Lab Manager:邢姝丽(Ashley Xing) 

    博士后PostdocsPoulomi Dey,彭莉华(Lisa Peng) 

    研究助理Research Assistants:温祥(Xiang Wen)、冯盼盼(Panpan Feng)

    硕士研究生Master Students:张书宁(Shuning Zhang)、党海月(Asper Dang)Xiao Yuan (On rotation), Abubakari Abdul-Wasid.

     

    毕业研究生(Graduate student)

    Nil

     

    招生信息(admission information)

    Welcome the students who are keen on microbiology, cancer and aging to join in us.