1. Cannavino J, Shao M, An YA, Bezprozvannaya S, Chen S, Kim J, Xu L, McAnally JR, Scherer PE, Liu N, Gupta RK, Bassel-Duby R, Olson EN. Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(23):e2104650118
2. Shao M, Hepler C, Zhang Q, Shan B, Vishvanath L, Henry GH, Zhao S, An YA, Wu Y, Strand DW, Gupta RK. Pathological HIF1a Signaling Drives Adipose Progenitor Dysfunction in Obesity. Cell Stem Cell. 2021;28(4):685-701 (Cover story; commented by Cell Stem Cell:“Bioenergetics matter to metabolic health-from a fat progenitor view”)
3. Shan B*, Shao M*, Zhang Q, Hepler C, Paschoal VA, Barnes SD, Vishvanath L, An YA, Malladi VS, Strand DW, Gupta OT, Oh D, Gupta RK. Perivascular Mesenchymal Cells Control Adipose Tissue Macrophage Accrual in Obesity. Nature Metabolism. 2020;2(11):1332-1349 (* Co-first author) (Highlighted by Nature Reviews Endocrinology)
4. Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA. Low- and High-thermogenic Brown Adipocyte Subpopulations Coexist in Murine Adipose Tissue. Journal of Clinical Investigation. 2020;130(1):247-257
5. An YA, Crewe C, Asterholm IW, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, Scherer PE. Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity. Nature Metabolism. 2019;1(12):1243-1257
6. Zhang Z*, Shao M*, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben AL, Wang M, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE. Dermal Adipose Tissue Has High Plasticity and Undergoes Reversible Dedifferentiation in Mice. Journal of Clinical Investigation. 2019;129(12):5327-5342 (* Co-first author)
7. Shao M*, Wang QA*, Song A, Vishvanath L, Busbuso NC, Scherer PE, Gupta RK. Cellular Origins of Beige Fat Cells Revisited. Diabetes. 2019;68:1874-1885 (* Co-first author)
8. Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O’Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P. A PRDM16 –Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metabolism. 2019;30:1-16
9. Shao M, Gupta RK. Transcriptional brakes on the road to adipocyte thermogenesis. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 2019;1864:20-28
10. Hepler C, Shan B, Zhang Q, Henry GH, Shao M, Vishvanath L, Ghaben AL, Mobley AB, Strand D, Hon GC, Gupta RK. Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. eLife. 2018;7:e39636
11. Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer PE. Reversible de-differentiation of mature white adipocytes into preadipocyte-like precursors during lactation. Cell Metabolism. 2018;28:282-288
12. Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar P, Gupta RK, Horton JD, Hill JA, Scherer PE. Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. Molecular Metabolism. 2018;11:1-17
13. Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE. Peroxisome proliferator-activated receptor g and its role in adipocyte homeostasis and thiazolidinedione-mediated insulin sensitization. Molecular and Cellular Biology. 2018;38:e00677-17
14. Roh HC, Tsai LT, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming induces significant reprogramming of beige, but not brown, adipocyte cellular identity. Cell Metabolism. 2018;27:1-17
15. Shao M, Vishvanath L, Busbuso NC, Hepler C, Shan B, Sharma AX, Chen S, Yu X, An YA, Zhu Y, Holland WL, Gupta RK. De novo adipocyte differentiation from Pdgfrb+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nature Communications. 2018;9:890
16. Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE. Intracellular lipid metabolism impairs b cell compensation during diet-induced obesity. Journal of Clinical Investigation. 2018;128(3):1178-1189
17. Zhang F, Hao G, Shao M, Nham K, An Y, Wang Q, Zhu Y, Kusminski CM, Hassan G, Gupta RK, Zhai Q, Sun X, Scherer PE, Oz OK. An adipose tissue atlas: An image-guided identification of human-like BAT and beige depots in rodents. Cell Metabolism. 2018;27:252-262
18. Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. Hepatic GALE regulates whole-body glucose homeostasis by modulating Tff3 expression. Diabetes. 2017;66:2789-2799
19. Hepler C, Shao M, Xia JY, Ghaben AL, Pearson MJ, Vishvanath L, Sharma AX, Morley TS, Holland WL, Gupta RK. Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. eLife. 2017;6:e27669
20. Tao C, Holland WL, Wang QA, Shao M, Jia L, Sun K, Lin X, Kuo YC, Johnson JA, Gordillo R, Elmquist JK, Scherer PE. Short-term versus long-term effects of adipocyte toll-like receptor 4 activation on insulin resistance in male mice. Endocrinology. 2017;158(5):1260-1270
21. Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan S, Liu Y. The metabolic ER stress sensor IRE1a suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nature Immunology. 2017;18:519-529
22. Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, His TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G. Regeneration of fat cells from myofibroblasts during would healing. Science. 2017;355:748-752
23. Shao M, Hepler C, Vishvanath L, MacPherson KA, Busbuso NC, Gupta RK. Fetal development of subcutaneous white adipose tissue is dependent on Zfp423. Molecular Metabolism. 2017;6:111-124
24. Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE. Connexin 43 mediates white adipose tissue beiging by facilitating the propagation of sympathetic neuronal signals. Cell Metabolism. 2016;24:420-433
25. Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK. Zfp423 maintains white adipocyte identity through suppression of the beige cell thermogenic gene program. Cell Metabolism. 2016;23:1167-1184
26. Vishvanath L, MacPherson KA, Hepler C, Wang QA, Shao M, Spurgin SB, Wang MY, Kusminski CM, Morley TS, Gupta RK. Pdgfrb+ mural preadipocytes contribute to adipocyte hyperplasia induced by high-fat-diet feeding and prolonged cold exposure in adult mice. Cell Metabolism. 2016;23:350-359
27. Ye R, Wang QA, Tao C, Vishvanath L, Shao M, McDonald JG, Gupta RK, Scherer PE. Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of cre recombinase. Molecular Metabolism. 2015;4:771-778
28. Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK and Scherer PE. Distinct regulatory mechanisms govern embryonic versus adult adipocyte maturation. Nature Cell Biology. 2015;17:1099-1111
29. Zhang H, Chen Y, Fan L, Xi Q, Wu G, Li X, Yuan T, He S, Yu Y, Shao M, Liu Y, Bai C, Ling Z, Li M, Liu Y, Fang J. The endoplasmic reticulum stress sensor IRE1a in intestinal epithelial cells is essential for protecting against colitis. The Journal of Biological Chemistry. 2015;290:15327-15336
30. Liu Y*, Shao M*, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y. Role for the endoplasmic reticulum stress sensor IRE1a in liver regenerative responses. Journal of Hepatology. 2015;62:590-598 (* Co-first author)
31. Ye R, Holland WL, Gordillo R, Wang M, Wang QA, Shao M, Morley TS, Gupta RK, Stahl A, Scherer PE. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes beta-cell regeneration. eLife. 2014;3:e03851
32. Jiang S, Yan C, Fang Q, Shao M, Zhang Y, Liu Y, Deng Y, Shan B, Liu J, Li H, Yang L, Zhou J, Dai Z, Liu Y, Jia W. Fibroblast growth factor 21 is regulated by the IRE1a-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. The Journal of Biological Chemistry. 2014;289:29751-29765
33. Shao M*, Shan B*, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y. Hepatic IRE1a regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARa axis signalling. Nature Communications. 2014;5:3528 (* Co-first author)
34. Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H, Zhu X. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. The Journal of Biological Chemistry. 2013;288:30087-30093
35. Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y. A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver x receptors. The Journal of Biological Chemistry. 2012;287:37973-37985
36. Shen H*, Shao M*, Cho KW, Wang S, Chen Z, Sheng L, Wang T, Liu Y, Rui L. Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and beta-cells. American Journal of Physiology- Endocrinology and Metabolism. 2012;302:E932-940 (* Co-first author)
37. Mao T*, Shao M*, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Y, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W, Liu Y. PKA phosphorylation couples hepatic inositol-requiring enzyme 1a to glucagon signaling in glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:15852-15857 (* Co-first author)
38. Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W, Liu Y. Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice. Journal of Lipid Research. 2010;51:2516-2526
39. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1a activation in pancreatic beta cells. Science Signaling. 2010;3:ra7
40. Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y. Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. Nutrition & Metabolism. 2010;7:59
