冯岁寒，化学生物学博士， 2014年毕业于欧洲分子生物学实验室(European Molecular Biology Laboratory, EMBL)，2015年至2021年进入日内瓦大学生物化学系和NCCR Chemical Biology从事博士后研究。2021年6月加入中科院上海巴斯德研究所和微生物、发育与健康研究中心(CMDH)，担任研究员、博士生导师，致力于建设一个包括合成化学，代谢和脂组学，生物化学在内的跨学科课题组，研究小分子和脂类在细胞及体内的代谢和运转。

17. Chang D., Lindberg E., Feng S., Angerani S., Riezman H., Winssinger N., Luciferase-Induced Photouncaging: Bioluminolysis. Angew. Chem. Int. Ed., 2019, 58, 16033-16037. Internet Link

16. Morstein J., Hill R. Z., Novak A. J. E., Feng S., Norman D. D., Donthamsetti P. C., Frank J. A., Harayama T., Williams B. W., Parrill A. L., Tigyi G. T., Riezman H., Isacoff E. Y., Bautista D. M., Trauner D., Optical Control of S1P Formation and Function. Nat. Chem. Biol., 2019, 15, 623-631. Internet Link

15. Feng S., Harayama T., Chang D., Hannich J. T., Winssinger N., Riezman H., Lysosome targeted photoactivation reveals local sphingosine metabolism signature. Chem. Sci., 2019, 10, 2253-2258. (cover picture, featured as 2019 Chemical Science HOT Article Collection) Internet Link

14. Feng S., Harayama T., Montessuit S., David F., Winssinger N., Martinou J-C., Riezman H., Mitochondria-specific photoactivation to monitor local sphingosine metabolism and functions. eLife, 2018, 7, e34555 Internet Link

13. Hannich J. H., Mellal D, Feng S., Zumbuehl A., Riezman H., Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans. Chem. Sci., 2017, 8, 3676-3686. Internet Link

12. Schifferertext M.*, Feng S.*, Stein F., Tischer C., Schultz C., Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane. Bioorg. Med. Chem., 2015, 23, 2862-2867. (*co-first author) Internet Link

11. Nadler A., Yushchenko D., Mueller R., Stein F., Feng S., Mulle C., Carta M., Schultz C., Exclusive photorelease of signalling lipids at the plasma membrane. Nat. Commun., 2015, 6, 10056.

10. MacNamara A., Stein F., Feng S., Schultz C., Saez-Rodriguez J., A single-cell model of PIP3 dynamics using chemical dimerization. Bioorg. Med. Chem., 2015, 23, 2868-2876.

9. Rutkowska A., Plass T., Hoffmann J. E., Yushchenko D., Feng S., Schultz C., T-CrAsH: A heterologous chemical crosslinker. ChemBioChem, 2014, 15, 1765-1768.

8. Feng S., Laketa V., Stein F., Rutkowska A., MacNamara A., Depner S., Klingmueller U., Saez-Rodriguez J., C Schultz, A rapidly reversible chemical dimerizer system to study lipid signalling in living cells. Angew. Chem. Int. Ed., 2014, 53, 6720-6723 (selected as a VIP paper, featured in ChemBioChem) Internet Link

7. Nadler A., Reither G., Feng S., Stein F., Reither S., Mueller R., Schultz C., The fatty acid composition of diacylglycerols determines local signaling patterns. Angew. Chem. Int. Ed., 2013, 52, 6330-6334.

6. Baldridge A., Feng S., Chang Y.-T., Tolbert L. M., Recapture of GFP chromophore fluorescence in a protein host. ACS Comb. Sci., 2011, 13, 214-217.

5. Lee J.-S., Baldridge A., Feng S., Yang S., Kim Y.-K., Tolbert L. M., Chang Y.-T., Fluorescence response profiling for small molecule sensors utilizing the green fluorescent protein chromophore and its derivatives. ACS Comb. Sci., 2011, 13, 32-38.

4. Lee J.-S., Kim H.-K., Feng S., Vendrell M., Chang Y.-T., Accelerating fluorescent sensor discovery: unbiased screening of a diversity-oriented BODIPY library. Chem. Commun., 2011, 47, 2339-2341.

3. Feng S., Kim Y.-K., Yang S., Chang Y.-T., Discovery of a Green DNA Probe for Live-Cell Imaging. Chem. Commun., 2010, 46, 436-438.

2. Lee J.-S., Kang N.-K., Kim Y.-K., Samanta A., Feng S., Kim H.-K., Vendrell M., Park J-H., Chang Y.-T., Synthesis of a BODIPY library and its application to the development of live cell glucagon imaging probe. J. Am. Chem. Soc., 2009, 131, 10077-10082.

1. Ji Q., Pang M., Han J., Feng S., Zhang X., Ma Y., Meng J., A simple and efficient synthesis of 2-deoxy-L-ribose from 2-deoxy-D-ribose. Synlett, 2006, 15, 2498-2500

Poster prize in 2020 International Symposium on Chemical Biology

脂类分子是所有生命体的基本形式，在维持生命体的技能方面有着不可替代的左右，很多代谢类的慢性疾病和脂类有关。但由于研究手段的缺乏，目前我们对于脂类的认识还停留在非常基础的阶段，很多原则性的问题还没有解决。在博士后期间，我开发了一种新的化学生物学技术，结合高分辨质谱，能够在亚细胞层面上追踪鞘脂（sphingolipid）的代谢。

在未来，结合研究所以及发育与健康微生物研究中心的专长，我们课题组的研究主要集中在以下领域：1、开发基于化学生物学的新技术用来精确地运送和追踪脂类分子；2、开发代谢和脂组学技术 (metabolomics and lipidomics)，研究各类小分子在肠道菌群和宿主互动中的作用、机理，以及它们对长期健康的影响；3、在细胞器水平(subcellular level)上研究脂类代谢和运输的机制。

实验室成员(Lab member)

招生信息(admission information)

欢迎具有生物学和化学背景的优秀学生加入本团队攻读硕士和博士研究生。

欢迎大学二年级（含）以上同学进入实验室参与有关科研学术工作，或联系毕业设计等。