研究组长
姓名: 酒亚明 性别:
学历: 博士
专家类别: 职称:
所属部门: 病原宿主互作的细胞生物学及光学成像研究组 学科类别: 生物学
联系电话: 电子邮箱: ymjiu@@ips.ac.cn
通讯地址: 上海市徐汇区岳阳路320号新生命科学研究大楼

个人简介:
  酒亚明,博士生导师,本科毕业于华中科技大学生物医学工程专业。中科院生物物理研究所与华中科技大学联合培养下获得生物物理专业博士学位。随后师从芬兰科学院院士Pekka Lappalainen教授进行博士后研究,期间主持芬兰国家科学院基金。2017年获得赫尔辛基大学助理教授教职。2018年入职上海巴斯德研究所,建立病原宿主互作的细胞生物学及光学成像实验室,担任研究组长。2019年获上海市人才发展资金。

  酒亚明博士主要以生物成像为技术特长,聚焦细胞骨架的动态调控与生理病理功能,从识别因子、明确信号、解析互作模式 、探寻靶点四个层次入手,研究细胞骨架对细胞迁移与病原感染的调控。目前在国际专业期刊发表四十余篇SCI研究论文,其中以通讯作者在PNASJournal of Cell Biology, Current Biology等杂志发表论文二十余篇,以共同作者在Nature CommunicationsJournal of HepatologyPLoS PathogensLight: Science and Application等杂志发表论文十余篇。多篇论文被Faculty of 1000 Prime作为 “Interesting Hypothesis”“New Finding”“Technical Advance”推荐,被Nature Reviews Molecular Cell BiologyNature Cell BiologyNature Materials等杂志点评引用,并被多家新闻媒体报导,有3篇工作被推荐为杂志封面论文。

  

研究方向:
  细胞骨架网络对细胞结构和功能起重要作用。微丝调控细胞黏附、运动和分裂;中间丝维持细胞形态、弹韧性并作为信号转导的枢纽。这些骨架和非骨架功能本质是由其组装、动态维持及交互调控共同决定的,例如细胞的运动取决于微丝的组装及与中间丝的互作、细胞分裂取决于微管、细胞的机械感受取决于微丝应力纤维的平衡维持、细胞应激下的完整性取决于中间丝的动态重组等。因此,对细胞骨架进行全面系统研究具有重要的生物学意义。重要的是,感染进程中宿主细胞骨架被病原体操纵和胁迫是其实现感染的必需条件。开展宿主细胞骨架体系调控病原体感染的机制研究,将不仅突破我们对病原体利用宿主细胞骨架促进自身感染策略的认识,也是发现新药靶的重要手段,同时也是我们全面认识细胞骨架病理功能的重要途径。课题组将开展以下几方面内容的研究:

  1)细胞骨架调控病原体感染研究。

  2)细胞骨架调控细胞结构和行为研究。

  3)相关光学显微成像技术和探针的新功能改进和新技术研发。

  代表性论文(#第一作者、*通讯作者):

  1.       Zhang Y#, Zhao S, Li Y, Feng F, Li M, Xue Y, Cui J, Xu T, Jin X*, Jiu Y* “Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication”. Proc Natl Acad Sci U S A. Feb 22;119(8):e2113909119. doi: 10.1073/pnas.2113909119. 2022.

  2.       Fan C#, Shi X, Zhao K, Wang L, Shi K, Liu Y, Li H, Ji B, Jiu Y* “Cell migration orchestrates migrasome formation by shaping retraction fibers” Journal of Cell Biology. Apr 4;221(4): e202109168. doi: 10.1083/jcb.202109168. 2022.

  3.       Shi X#, Tang D#, Xing Y#, Zhao S, Fan C, Zhong J, Cui Y*, Shi K*, Jiu Y* “Actin nucleator formins regulate the tension-buffering function of caveolin-1” Journal of Molecular Cell Biology. Jan 29;13(12):876-888. doi: 10.1093/jmcb/mjab070. 2021.

  4.       Liu W#, Tang D#, Xu X, Liu Y*, Jiu Y* “How physical factors coordinate virus infection a perspective from mechanobiology”. Frontiers in Bioengineering and Biotechnology. Oct 29;9:764516. doi: 10.3389/fbioe.2021.764516. 2021.

  5.       Shi X#, Wen Z, Wang Y, Liu Y, Shi K, Jiu Y* “Feedback-driven mechanisms between phosphorylated caveolin-1 and contractile actin assemblies instruct persistent cell migration” Frontiers in Cell and Developmental Biology. Apr 12;9:665919. doi: 10.3389/fcell.2021.665919. 2021.

  6.       Wen G#, Li S, Wang L, Chen X, Sun Z, Liang Y, Jin X, Xing Y, Jiu Y, Tang Y, Li H* “High-fidelity structured illumination microscopy by point-spread-function engineering” Light: Science & Application. Apr 1;10(1):70. doi: 10.1038/s41377-021-00513-w. 2021.

  7.       Ouyang Z#, Zhao S#, Yao S, Wang J, Cui Y, Wei K*, Jiu Y* “Multifaceted function of myosin-18, an unconventional class of the myosin superfamily”. Frontiers in Cell and Developmental Biology. Feb 9;9:632445. doi: 10.3389/fcell.2021.632445. 2021.

  8.       Zhang Y#, Wen Z, Shi X, Liu Y, Eriksson J*, Jiu Y* “The diverse roles and dynamic rearrangement of vimentin during virus infection”. Journal of Cell Science. Nov 5;134(5):jcs250597. doi: 10.1242/jcs.250597. 2020.

  9.       Zhao S#, Shi X#, Zhang Y#, Wen Z, Cai J, Gao W, Xu J, Zheng Y, Ji B, Cui Y, Shi K, Liu Y, Li H, Jiu Y*, “Myosin-18B promotes mechanosensitive CaMKK2-AMPK-VASP regulation of contractile actin stress fibers”. iScience. Apr 24;23(4):100975. doi: 10.1016/j.isci.2020.100975. 2020.

  10.   Wen Z#, Zhang Y#, Lin Z, Shi K, Jiu Y*, “Cytoskeleton - a crucial key in host cell for coronavirus infection”. Journal of Molecular Cell Biology. Dec;12(12):968-79. doi: 10.1093/jmcb/mjaa042. 2020.

  11.   Xing Y#, Wen Z#, Gao W, Lin Z, Zhong J, Jiu Y*, “Multifaceted functions of host cell caveolae/caveolin-1 in virus infections”. Viruses. Apr 26; 12(5):E487. doi: 10.3390/v12050487. 2020.

  12.   Kumari R#, Jiu Y, Carman P, Tojkander S, Kogan K, Varjosalo M, Gunning P, Dominguez R, Lappalainen P* “Tropomodulins control balance between protrusive and contractile structures in migrating cells by stabilizing actin-tropomyosin filaments”. Current Biology. Mar 9;30(5):767-778.e5. doi: 10.1016/j.cub.2019.12.049. 2020.

  13.   Zhao S#, Cai J#, Zhang X, Cui J, Jiu Y* “Different formins restrict localization of distinct tropomyosins on dorsal stress fibers in osteosarcoma cells”. Cytoskeleton (Hoboken). Jan;77(1-2):16-24. doi: 10.1002/cm.21588. 2020.

  14.   Jiu Y#*, Kumari R, Fenix A, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette D, Lappalainen P* “Myosin-18B promotes the assembly of myosin II stacks to drive maturation of contractile actomyosin bundles”. Current Biology. Jan 7;29(1):81-92.e5. doi: 10.1016/j.cub.2018.11.045. 2019.

  15.   Shi X#, Zhao S, Cai J, Wong G, Jiu Y* “Active FHOD1 promotes the formation of functional actin stress fibers”. Biochemical Journal. Oct 30;476(20):2953-2963. doi: 10.1042/BCJ20190535. 2019.

  16.   Li J#, Gao W#, Zhang Y#, Cheng F, Eriksson J, Etienne-Manneville S, Jiu Y* “Engagement of vimentin intermediate filaments in hypotonic stress”. Journal of Cellular Biochemistry. Aug;120(8):13168-13176. doi: 10.1002/jcb.28591. 2019. (IF 4.429)

  17.   Deng L#, JiangW, Wang X, Merz A, Hiet M, ChenY, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G* “Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes”. Journal of Hepatology. Jul;71(1):52-61. doi: 10.1016/j.jhep.2019.03.006. 2019.

  18.   Li J#, Zou Y, Li Z, Jiu Y* “Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling”. Science China Life Sciences.  Oct;62(10):1368-1374. doi: 10.1007/s11427-018-9488-1. 2019.  

  19.   Zhang Y#, Gao W, Li J, Wu W, Jiu Y* “The role of host cytoskeleton in flavivirus infection”. Virologica Sinica. 2019 Feb;34(1):30-41. doi: 10.1007/s12250-019-00086-4. 2019.

  20.   Liu X#, Salokas K, Tamene F, Jiu Y, Weldatsadik R, ?hman T, Varjosalo M* “An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations”. Nature Communications. Mar 22; 9(1):1188. doi: 10.1038/s41467-018-03523-2. 2018.

  21.   Jiu Y#*, Per?nen J, Schaible N, Cheng F, Eriksson J, Krishnan R, Lappalainen P* “Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA”. Journal of Cell Science. Jan 18; 130(5): 892-902. doi: 10.1242/jcs.196881. 2017.

  22.   Jiu Y#, Lehtim?ki J, Tojkander S, Cheng F, J??linoja H, Liu X, Varjosalo M, Eriksson J, Lappalainen P* “Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers”. Cell Reports. Jun 16; 11(10):1511-1518. doi: 10.1016/j.celrep.2015.05.008. 2015.

  23.   Weinheimer I#, Jiu Y#, Rajam?ki M#, Matilainen O, Kallij?rvi J, Cuellar W, Lu R, Saarma M, Holmberg C, J?ntti J, Valkonen J* “Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants”. PLoS Pathogens. Mar 6; 11(3):e1004711. doi: 10.1371/journal.ppat.1004711. 2015.

  24.   Yu Y#, Wang L#, Jiu Y#, Zhan Y, Liu L, Xia Z, Song E, Xu P*, Xu T* “HID-1 is a novel player in the regulation of neuropeptide sorting”. Biochemical Journal. Feb 24; 434(3):383-390. doi: 10.1042/BJ20110027. 2011.

  25.   Jiu Y#, Yue Y#, Yang S#, Liu L, Yu J, Zhang R, Wu Z*, Xu T* “Insulin-like signaling pathway for decision making behavior in C. elegans”. Protein Cell. Jan;1(1):75-81. doi: 10.1007/s13238-010-0003-4. 2010.

  26.   Jiu Y#, Hu Z#, Liu J#, Wu Z*, Xu T* “α-LTX and α-LTXN4C induce [Ca2+]i elevation through different mechanisms in pancreatic β cells”. Chinese Science Bulletin. Jan; 51(2):158-163. doi: 10.1007/s11434-005-1029-5. 2006.

  27.   李剑,酒亚明*。中间纤维的功能和研究进展。中国细胞生物学学报,41(3). doi: 10.11844/cjcb.2019.03.0283. 2019 (特邀综述)

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