2019-present, Professor, Principal investigator, Institut Pasteur of Shanghai, CAS
2016-2018, Research director, Institut Pasteur, Paris, France
2009-2016, Laboratory chief, Institut Pasteur, Paris, France
The general purpose of my current studies is to fullfill the gaps of knowledge of the immune system during the first 1,000 days of life in the evolving context of the microbial colonization following birth. The use of high-end technologies in pediatric immunology offers a potent mean to investigate the impact of human microbiota on child health and disease. My latest achievements concern the characterization of immune biomarkers of disease severity in bronchiolitis and in neonatal sepsis, with a particular focus on unique regulatory aspects of the perinatal immune system. The contribution of environmental factors during pregnancy, such as mild or chronic infectious diseases, malnutrition or medication, in the development of the newborn immunity, represents an important line of research as well.
- Development of a therapeutic cancer vaccine up to phase I clinical trial
- 1st evidence of fetal Breg development and characterization of a biomarker of RSV induced bronchiolitis in newborns.
- 1st demonstration of the capacity of newborn moDC to induce neonatal TH1 reponses. Demonstration of an alternative pathway for new adjuvant design for pediatric vaccination.
- 1st evidence of fetal development of memory T cell in humans.
- 1st evidence of regulatory of neutrophils. Demonstration provided in the context of TB infection.
- Demonstration that IFNI-IL10 crosstalk suppresses neonatal lethal inflammation.
- 1st evidence of regulatory B cells in a neonatal setting.
1. Zhivaki D, Lo-Man R. T cell memory in utero. Seminars in Immunpathology. 2017;39(6):585-592.(IF=6.5)
2. Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Herve PL, Deriaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eleouet JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissieres P, Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity. 2017;46(2):301-314. (IF 21.5)
3. Zhang X, Zhivaki D, Lo-Man R. Unique aspects of the perinatal immune system. Nature reviews Immunology. 2017;17(8):495-507. (IF=42)
4. Lemoine S, Jaron B, Tabka S, Ettreiki C, Deriaud E, Zhivaki D, Le Ray C, Launay O, Majlessi L, Tissieres P, Leclerc C, Lo-Man R. Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells. The Journal of allergy and clinical immunology. 2015;136(5):1355-1368 e1315. (IF=14)
5. Zhang X, Mozeleski B, Lemoine S, Deriaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med. 2014;6(238):238ra272. (IF=17)