Name: | Guangxun MENG | ||
---|---|---|---|
Unit Name: | Unit of Innate Immunity | ||
Education(CV): |
Guangxun Meng obtained his Ph.D from the Technical University of Munich in Germany in 2004. In 2005, he went to the National Institute of Allergy and Infectious Diseases at NIH in the United States for Post.Doc. training. In 2010, he started to work as a Principal Investigator at the Institut Pasteur of Shanghai, Chinese Academy of Sciences, China. |
||
Email: | gxmeng@ips.ac.cn |
Research Topic: |
---|
Homeostasis in barrier organs such as gut, lung and skin is crucial for health and disease. Dynamic interaction and reciprocal regulation between resident microbes and host immune system involving tissue epithelial and stromal elements is key for maintaining homeostasis locally and systemically. The dialogue between host and microbes is largely mediated by pattern recognition receptors (PRRs) mainly expressed by innate immune cells and tissue resident non-immune cells. Inflammatory responses following PRR recognition of microbes can be either beneficial or detrimental. Function and mechanism study for inflammation is a focus of our lab. We are particularly interested in inflammasome-, microbiota-, cell death-, metabolite-, mucosal-related researches applying various in vitro and in vivo disease models. |
Team Members: |
---|
Selected Bibliography : |
---|
1. Yao X#, Zhang C#, Xing Y#, Xue G, Zhang Q, Pan F, Wu G, Hu Y, Guo Q, Lu A, Zhang X, Zhou R, Tian Z, Zeng B, Wei H, Strober W, Zhao L*, Meng G*.Hyperactive NLRP3 inflammasome neutralizes gut inflammation through remodeling of the microbiota. Nat Commun. 2017 Dec 1;8(1):1896. doi: 10.1038/s41467-017-01917-2. PMID: 29196621. 2. Xing Y#, Yao X#, Li H, Xue G, Guo Q, Yang G, An L, Zhang Y, Meng G*.Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome. J Immunol. 2017 Jul 24. doi: 10.4049/jimmunol.1700175. PMID: 28739881. 3. Chen M, Xing Y, Lu A, Fang W, Sun B, Chen C, Liao W, Meng G*. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes. J Immunol. 2015 Oct 14. pii: 1500865. PMID: 26466953. 4. Meng G, Zhang F, Fuss I, Kitani A, Strober W*. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity. 2009 Jun 19;30(6):860-74. “Must read” paper in Faculty of 1000. PMID: 19501001. 5. Meng G#, Rutz M#, Schiemann M, Metzger J, Grabiec A, Schwandner R,Luppa PB, EbelF,Busch DH, Bauer S, Wagner H, Kirschning CJ*. Antagonistic antibody prevents Toll-like receptor 2 driven lethal shock-like syndromes. J Clin Invest. 2004 May 15; 113:1473-81. Recommended” paper in Faculty of 1000. PMID: 15146245. . |