Principal Investigators

Principal Investigators
Name: Richard LO-MAN
Unit Name: Unit of Immunity and Pediatric Infectious Diseases

I developed my scientific career in the field of immunology in many areas, encompassing vaccine science, cancer immunotherapy, and pediatric infectious diseases, from basic science to clinical human studies.


Research Topic:

The general purpose of my current studies is to fullfill the gaps of knowledge of the immune system during the first 1,000 days of life in the evolving context of the microbial colonization following birth. The use of high-end technologies in pediatric immunology offers a potent mean to investigate the impact of human microbiota on child health and disease. My latest achievements concern the characterization of immune biomarkers of disease severity in bronchiolitis and in neonatal sepsis, with a particular focus on unique regulatory aspects of the perinatal immune system. The contribution of environmental factors during pregnancy, such as mild or chronic infectious diseases, malnutrition or medication, in the development of the newborn immunity, represents an important line of research as well.


Unit Logo:


Team Members:

Richard LO-MAN: Principal Investigator


Shijie GONG
Zihan HE

Qisheng GU



Cynthia-Dewi BETTER


Zhicheng HUANG


Selected Bibliography :

1. Zhang X, Zhivaki D, Lo-Man R. Unique aspects of the perinatal immune system. Nature reviews Immunology (IF=42). 2017;17(8):495-507. 
2. Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Herve PL, Deriaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eleouet JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissieres P, Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity (IF=21.5). 2017;46(2):301-314.
3.  Lemoine S, Jaron B, Tabka S, Ettreiki C, Deriaud E, Zhivaki D, Le Ray C, Launay O, Majlessi L, Tissieres P, Leclerc C, Lo-Man R. Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells. The Journal of allergy and clinical immunology (IF=14.1). 2015;136(5):1355-1368 e1315.
4.  Zhang, X., Mozeleski, B., Lemoine, S., Deriaud, E., Lim, A., Zhivaki, D., Azria, E., Le Ray, C., Roguet, G., Launay, O., Vanet, A., Leclerc, C. and Lo-Man, R., CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med (IF=17 ;1), 2014. 6(238): p. 238ra72.
5.  Zhang, X., Majlessi, L., Deriaud, E., Leclerc, C. and Lo-Man, R., Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity (IF=21.5), 2009; 31(5):761-771.