Principal Investigators----中国科学院上海巴斯德研究所

Principal Investigators

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Principal Investigators

Name:	Lanfeng WANG
Unit Name:	Unit of Structural Biology of Pathogenesis
Education(CV):	2016-present: Principal investigator, head of the Structural Biology of Pathogenesis Unit, Institut Pasteur of Shanghai, Chinese Academy of Sciences 2010-2015: Postdoc, University of California, San Diego 2006-2010: PhD, Institute of Biophysics, Chinese Academy of Sciences 2002-2005: Master, Nanjing Agricultural University
Email:	lanfwang@ips.ac.cn

Research Topic:
Our research interest focuses on the structural mechanism of the interaction between pathogen and host. We propose to determine the three dimensional structures of important macromolecular machineries involved with pathogen entry, replication, host anti-pathogen response, and et al. using multidisciplinary tools (Cryo-Electron Microscope, X-ray crystallography, Biochemistry and et al.). Once the structures are solved, we may analyze the important interfaces within protein machinery, antigen antibody complex, or active sites in enzymes. On one hand, the structure information may help characterize the biological macromolecules (architecture, regulatory network, and et al.); On the other hand, structure-based screening of the anti-pathogen pro-drugs or design of new vaccines based on various epitopes can be carried out.

Research Topic:

Our research interest focuses on the structural mechanism of the interaction between pathogen and host. We propose to determine the three dimensional structures of important macromolecular machineries involved with pathogen entry, replication, host anti-pathogen response, and et al. using multidisciplinary tools (Cryo-Electron Microscope, X-ray crystallography, Biochemistry and et al.). Once the structures are solved, we may analyze the important interfaces within protein machinery, antigen antibody complex, or active sites in enzymes. On one hand, the structure information may help characterize the biological macromolecules (architecture, regulatory network, and et al.); On the other hand, structure-based screening of the anti-pathogen pro-drugs or design of new vaccines based on various epitopes can be carried out.

Team Members:
Lanfeng WANG: Principal Investigator Jin SUN: Associate Professor Rui TIAN: Technician Weiwei WANG: PhD student Jun ZHANG: PhD student Duo JIN: PhD student Qian LI: PhD student Hongshuai LU: MS student Zhaoning WANG: MS student Lingyu ZHAO: MS student Tong CHENG: MS student Qian XU: Undergraduate student

Selected Bibliography :
1. Zhou, H.,§, Wang, F.§, Wang, H.§, Chen C, Zhang T, Han X, Wang D, Chen C, Wu C, Xie W, Wang Z, Zhang L, *Wang L,** Yang H* The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget (2017) (, co-corresponding Author) 2. Wang, L.,* §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D., and Wang, D. Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author) ？ 3. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci U S A 111, 18566-18571 (2014). (§, Co-First Author) 4. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. & Rao, Z. Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

Selected Bibliography :

1. Zhou, H.,§, Wang, F.§, Wang, H.§, Chen C, Zhang T, Han X, Wang D, Chen C, Wu C, Xie W, Wang Z, Zhang L, Wang L*, Yang H* The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget (2017) (*, co-corresponding Author)

2. Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D.*, and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author) ？

3. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci U S A 111, 18566-18571 (2014). (§, Co-First Author)

4. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. & Rao, Z. Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

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