Principal Investigators

Principal Investigators
Name: Xiaoming ZHANG
Unit Name: Unit of Innate Defense and Immune Modulation
Education(CV):

2004–2007: PhD of Immunology, University Paris VI, France.

2007–2012: Postdoc, Institut Pasteur, France.

2012–: Professor/Principal Investigator, Institut Pasteur of Shanghai, China.

 
Email: xmzhang@ips.ac.cn

Research Topic:

1. Immune regulation at the interface between fetus and mother                           

We are applying scRNAseq, high-dimensional flow cytometry and multi-color immunohistochemistry to dissect the immune factors in the regulation of a successful pregnancy and to identify key immune abnormalities responsible for recurrent spontaneous abortion. The association of host gut microbiota and the disease will be investigated too. 


2. Gut immune microenvironment of Necrotizing enterocolitis (NEC)

NEC is a severe disease affecting neonates, particularly preterm babies. With a similar research strategy as above, we are dissecting the immune compartment in the gut of NEC patients and adjacent normal tissues in relation to gut microbiota changes. 


3. Longitudinal analysis of single B cell and T cell repertoire during childhood
Team Members:

Xiaoming ZHANG: Principal Investigator

Lu MENG: Associate Professor

Shyamal GOSWAMI: Assistant Professor

Teng LI: Assistant Professor

Meiying ZHANG: Research Assistant

Saif AFRIDI: Joint Postdoctoral Fellow

Huihui XU: PhD student

Yumeng SUN: PhD student

Guohe SONG: PhD student

Shuaixi YANG: PhD student

Zechuan CHEN: MS student

Yida LI: MS student

 
Selected Bibliography :

(*: Corresponding author)

1.      Wu CM, Fu Q, Guo Q, Chen S, Goswami S, Sun SH, Li T, Cao XJ, Chu FY, Chen ZC, Liu M, Liu YH, Fu T, Hao P, Hao Y, Shen N, Bao CD*, Zhang XM*. Lupus associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated. Ann Rheum Dis. 2019, DOI: 10.1136/annrheumdis-2019-215039.

2.      Liu M, Guo Q, Wu CM, Sterlin D, Goswami S, Zhang Y, Li T, Bao CD, Shen N, Fu Q* and Zhang XM*. Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients. Cell Mol Immunol. 2019, 16:367–379.

3.      Duan M, Goswami S, Shi JY, Wu LJ, Wang XY, Ma JQ, Zhang Z, Shi Y, Ma LJ, Zhang S, Xi RB, Cao Y, Zhou J, Fan J*, Zhang XM* and Gao Q*. Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma. Clin Cancer Res. 2019, 25: 3304-3316.

4.      Zhang XMΔ, Mozeleski BΔ, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med. 2014 6(238):238ra72. (Δ: equal contribution) 

5.      Zhang XM, Majlessi L, Deriaud E, Leclerc C and Lo-Man R. Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity. 2009, 31: 761-771.