| Name: | Xing LIU | ||
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| Unit Name: | Unit of Anti-Infective Immunity and Immune Diseases | ||
| Education(CV): | 2018- present, Principle investigator, Institut Pasteur of Shanghai, CAS |
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| Email: | xingliu@ips.ac.cn | ||
| Research Topic: |
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| Our lab focuses on innate immune responses and related immune diseases and aims to reveal the novel mechanisms of immune responses and immune regulations by using cell-based infection models and animal diseases models. Based on our expertise and experience, our lab will further study (1) the relationship between gut microbiota and immune system, and explore strategies to manipulate gut microbiota in order to treat associated human diseases; (2) identify and test non-canonical inflammasome inhibitors as a novel strategy for preventing or treating sepsis; (3) assess roles of other Gasdermin family members in protecting against invading pathogens. These studies will further deepen our understanding of host-microbial interactions.
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| Team Members: |
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| Selected Bibliography : |
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1. Senlin Li, Ze Hong, Zhe Wang, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen, Qiang Wang, Heng Liu, Yanni Cai, Huansha Yu, Huimin Xu, Guangzhi Zeng, Quanyi Wang, Juanjuan Zhu, Xing Liu, Ninghua Tan, and Chen Wang (2018). The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Reports, 25(12): 3405-3421. 2. Xing Liu*, Rui Fu*, Youdong Pan, Karla Meza-Sosa, Zhibin Zhang and Judy Lieberman (2018). PNPT1 release from mitochindria during apoptosis triggers decay of polyadenylated RNAs. Cell, 174(1):187-201. *Co-first author 3. Ye Cui, Huansha Yu, Xin Zheng, Rui Peng, Qiang Wang, Yi Zhou, Rui Wang, Jiehua Wang, Bo Qu, Nan Shen, Qiang Guo, Xing Liu, Chen Wang (2017). SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing. PLoS Pathogens, 13(1): e1006156. Co-corresponding author 4. Xing Liu*, Zhibin Zhang*, Jianbin Ruan*, Youdong Pan, Venkat Giri Magupalli, Hao Wu, and Judy Lieberman (2016). Inflammasome-activated Gasdermin D causes pyroptosis by forming membrane pores. Nature, 535: 153-158. *Co-first author 5. Qiang Wang*, Xing Liu*, Ye Cui, Yijun Tang, Wei Chen, Senlin Li, Huansha Yu, Youdong Pan, and Chen Wang (2014). The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING. Immunity, 41(6): 919-33. Cover Article. *Co-first author and *Co-corresponding author |