| Name: | Mengle SHAO | ||
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| Unit Name: | Unit of Microbiota and Metabolic Diseases | ||
| Education(CV): |
2021.07-present, Principal investigator, Institut Pasteur of Shanghai, CAS 2013.02-2013.10, Postdoctoral researcher, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, CAS 2007.09-2013.01, Ph.D., Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, CAS |
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| Email: | mlshao@ips.ac.cn | ||
| Research Topic: |
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The global prevalence of obesity places a growing number of individuals on the risk of developing chronic metabolic disease. However, effective therapeutics for the prevention and treatment of obesity are still very limited, which urges new discoveries of new therapeutic targets and strategies to combat against obesity and its comorbidities. One of the determinants of metabolic health in obesity is the mode by which metabolic organs (e.g. adipose tissue, liver, etc.) remodel in the setting of excessive caloric intake. Our labs focus on the investigation the key events of metabolic organ remodeling in multiple physiological and pathological settings. Our previous and ongoing projects employ state-of-the-art approaches including inducible genetic models, single-cell/nucleus technologies, multi-omics analysis, and advanced imaging systems to extensively explore the plasticity, complexity and heterogeneity of metabolic organs at cellular and molecular levels. We aim to elucidate how the key factors (such as nutrient status and host-microbial homeostasis) determine metabolic organs remodeling modes, with the hope of opening new pharmacological opportunities of utilizing these regulatory mechanisms to promote metabolic organ health and maintain metabolic health in obesity. |
| Team Members: |
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| Positions available |
| Selected Bibliography : |
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1. Shao M, Hepler C, Zhang Q, Shan B, Vishvanath L, Henry GH, Strand DW, Gupta RK. Pathological HIF1 Signaling Drives Adipose Progenitor Dysfunction in Obesity. Cell Stem Cell. 2021;28(4):685-701 (Cover story; commented by Cell Stem Cell) 2. Shan B*, Shao M*, Zhang Q, Hepler C, Paschoal VA, Barnes SD, Vishvanath L, An YA, Malladi VS, Strand DW, Gupta OT, Oh D, Gupta RK. Perivascular Mesenchymal Cells Control Adipose Tissue Macrophage Accrual in Obesity. Nat Metab. 2020;2(11):1332-1349 (* Co-first author) (Highlighted by Nature Reviews Endocrinology) 3. Zhang Z*, Shao M*, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben AL, Wang M, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE. Dermal Adipose Tissue Has High Plasticity and Undergoes Reversible Dedifferentiation in Mice. J Clin Invest. 2019;129(12):5327-5342 (* Co-first author) 4. Shao M, Vishvanath L, Busbuso NC, Hepler C, Shan B, Sharma AX, Chen S, Yu X, An YA, Zhu Y, Holland WL, Gupta RK. De novo adipocyte differentiation from Pdgfr？+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat Commun. 2018;9:890 5. Shao M, Hepler C, Vishvanath L, MacPherson KA, Busbuso NC, Gupta RK. Fetal development of subcutaneous white adipose tissue is dependent on Zfp423. Mol Metab. 2017;6:111-124 |