Principal Investigators----中国科学院上海巴斯德研究所

Principal Investigators

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Principal Investigators

Name:	Philippe SANSONETTI
Unit Name:	Unit of Molecular Microbial Pathogenesis and Symbiosis
Education(CV):	Professor, Chair of Microbiology and Infectious Diseases, Collège de France, Paris Emeritus Professor, Institut Pasteur Paris Professor, Head of The Center for Microbes, Development and Health, Institut Pasteur Shanghai and Chinese Academy of Sciences, Shanghai Principal Honors, Awards, Editorship and major grants EMBO member Member to the French Academy of Sciences Member to the Deutsche Akademie der Natursforscher Leopoldina Foreign member to the United States National Academy of Sciences Foreign Member to the Royal Society, London Senior Foreign Scholar of the Howard Hughes Medical Institute Louis-Jeantet Prize of Medicine Robert Koch Prize André Lwoff Medal (FEMS) Grand Prix de l’INSERM Grand Prix de la Fondation Recherche Médicale Awarded two European Research Council (ERC) Advanced Grants (2009-14 and 2014-19) Coordinator AFRIBIOTA Project (Fondation TOTAL): pediatric stunting in relation to environmental enteropathy in sub-saharan Africa (2015-19) Coordinator Large-Scale FP7 EU program STOPENTERICS to foster innovation in new-generation ETEC and Shigella vaccine development (2010-2017) Coordinator Laboratory of Excellence (Integrative Biology of Emerging Infectious Diseases), French National Program “Investments for the Future” (2010-19) Founder and past chief-editor of Cellular Microbiology Current Chief Editor, EMBO Molecular Medicine Direction of 12 MD Thesis, 20 PhD Thesis and 60 post-doctoral scientists Publications (ISI, April 2019) 575 publications in peer-reviewed international journals, 36 000 citations, h-index = 104 5 active patents
Email:	philippe.sansonetti@ips.ac.cn

Research Topic:
Our project will be two folds: 1. To decipher the logics of ecological successions that support the assembly of a fully mature gut microbiota from birth to 2-3 years of life and their subversion by interventions such as delivery by cesarean section, the use of antibiotics and other environmental factors including diet. This project will combine descriptive microbiological analysis in infants and experimental approaches combining in vitro analysis of bacterial episymbiosis by microfluidics- and fermentor-based techniques (i.e. artificial intestine), and in vivo approaches in mice. 2. To identify and experimentally validate the major mechanisms supporting the colonization barrier effect of the gut microbiota. We will specifically use enteropathogenic bacteria – such as Shigella - as probes to decipher the mechanistic bases of microbiota-conferred barrier to colonization by pathogens and the strategies used by these pathogens to subvert this colonization barrier effect.

Research Topic:

Our project will be two folds:

1. To decipher the logics of ecological successions that support the assembly of a fully mature gut microbiota from birth to 2-3 years of life and their subversion by interventions such as delivery by cesarean section, the use of antibiotics and other environmental factors including diet. This project will combine descriptive microbiological analysis in infants and experimental approaches combining in vitro analysis of bacterial episymbiosis by microfluidics- and fermentor-based techniques (i.e. artificial intestine), and in vivo approaches in mice.

2. To identify and experimentally validate the major mechanisms supporting the colonization barrier effect of the gut microbiota. We will specifically use enteropathogenic bacteria – such as Shigella - as probes to decipher the mechanistic bases of microbiota-conferred barrier to colonization by pathogens and the strategies used by these pathogens to subvert this colonization barrier effect.

Team Members:
Philippe SANSONETTI: Principal Investigator Yizhou GAO: Associate Professor Emilie CARLOT: Center Manager Linzuo TENG: Lab Manager Jiaxin GUO: MS student Wenyu JIN: Ms student Rongkang TANG: Research Assistant

Selected Bibliography :
1. Marteyn, B., West, N.P., Browning, D.F., Cole, J.A., Shaw, J.G., Palm, F., Mounier, J., Prévost, M.-C., Sansonetti, P., Tang, C.M., 2010. Modulation of Shigella virulence in response to available oxygen in vivo. Nature 465, 355–358. https://doi.org/10.1038/nature08970 2. Pédron, T., Mulet, C., Dauga, C., Frangeul, L., Chervaux, C., Grompone, G., Sansonetti, P.J., 2012. A crypt-specific core microbiota resides in the mouse colon. MBio 3. https://doi.org/10.1128/mBio.00116-12 3. Nigro, G., Rossi, R., Commere, P.-H., Jay, P., Sansonetti, P.J., 2014. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe 15, 792–798. https://doi.org/10.1016/j.chom.2014.05.003 4. Schnupf, P., Gaboriau-Routhiau, V., Gros, M., Friedman, R., Moya-Nilges, M., Nigro, G., Cerf-Bensussan, N., Sansonetti, P.J., 2015. Growth and host interaction of mouse segmented filamentous bacteria in vitro. Nature 520, 99–103. https://doi.org/10.1038/nature14027 5. Anderson, M.C., Vonaesch, P., Saffarian, A., Marteyn, B.S., Sansonetti, P.J., 2017. Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy. Cell Host Microbe 21, 769–776.e3. https://doi.org/10.1016/j.chom.2017.05.004 6. Aymeric, L., Donnadieu, F., Mulet, C., Merle, L. du, Nigro, G., Saffarian, A., Bérard, M., Poyart, C., Robine, S., Regnault, B., Trieu-Cuot, P., Sansonetti, P.J., Dramsi, S., 2018. Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization. PNAS 115, E283–E291. https://doi.org/10.1073/pnas.1715112115 7. Vonaesch, P., Morien, E., Andrianonimiadana, L., Sanke, H., Mbecko, J.-R., Huus, K.E., Naharimanananirina, T., Gondje, B.P., Nigatoloum, S.N., Vondo, S.S., Kandou, J.E.K., Randremanana, R., Rakotondrainipiana, M., Mazel, F., Djorie, S.G., Gody, J.-C., Finlay, B.B., Rubbo, P.-A., Parfrey, L.W., Collard, J.-M., Sansonetti, P.J., Investigators, T.A., 2018. Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa. PNAS 115, E8489–E8498. https://doi.org/10.1073/pnas.1806573115 8. Saffarian, A., Mulet, C., Regnault, B., Amiot, A., Tran-Van-Nhieu, J., Ravel, J., Sobhani, I., Sansonetti, P.J., Pédron, T., 2019. Crypt- and Mucosa-Associated Core Microbiotas in Humans and Their Alteration in Colon Cancer Patients. MBio 10. https://doi.org/10.1128/mBio.01315-19

Selected Bibliography :

1. Marteyn, B., West, N.P., Browning, D.F., Cole, J.A., Shaw, J.G., Palm, F., Mounier, J., Prévost, M.-C., Sansonetti, P., Tang, C.M., 2010. Modulation of Shigella virulence in response to available oxygen in vivo. Nature 465, 355–358. https://doi.org/10.1038/nature08970

2. Pédron, T., Mulet, C., Dauga, C., Frangeul, L., Chervaux, C., Grompone, G., Sansonetti, P.J., 2012. A crypt-specific core microbiota resides in the mouse colon. MBio 3. https://doi.org/10.1128/mBio.00116-12

3. Nigro, G., Rossi, R., Commere, P.-H., Jay, P., Sansonetti, P.J., 2014. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe 15, 792–798. https://doi.org/10.1016/j.chom.2014.05.003

4. Schnupf, P., Gaboriau-Routhiau, V., Gros, M., Friedman, R., Moya-Nilges, M., Nigro, G., Cerf-Bensussan, N., Sansonetti, P.J., 2015. Growth and host interaction of mouse segmented filamentous bacteria in vitro. Nature 520, 99–103. https://doi.org/10.1038/nature14027

5. Anderson, M.C., Vonaesch, P., Saffarian, A., Marteyn, B.S., Sansonetti, P.J., 2017. Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy. Cell Host Microbe 21, 769–776.e3. https://doi.org/10.1016/j.chom.2017.05.004

6. Aymeric, L., Donnadieu, F., Mulet, C., Merle, L. du, Nigro, G., Saffarian, A., Bérard, M., Poyart, C., Robine, S., Regnault, B., Trieu-Cuot, P., Sansonetti, P.J., Dramsi, S., 2018. Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization. PNAS 115, E283–E291. https://doi.org/10.1073/pnas.1715112115

7. Vonaesch, P., Morien, E., Andrianonimiadana, L., Sanke, H., Mbecko, J.-R., Huus, K.E., Naharimanananirina, T., Gondje, B.P., Nigatoloum, S.N., Vondo, S.S., Kandou, J.E.K., Randremanana, R., Rakotondrainipiana, M., Mazel, F., Djorie, S.G., Gody, J.-C., Finlay, B.B., Rubbo, P.-A., Parfrey, L.W., Collard, J.-M., Sansonetti, P.J., Investigators, T.A., 2018. Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa. PNAS 115, E8489–E8498. https://doi.org/10.1073/pnas.1806573115

8. Saffarian, A., Mulet, C., Regnault, B., Amiot, A., Tran-Van-Nhieu, J., Ravel, J., Sobhani, I., Sansonetti, P.J., Pédron, T., 2019. Crypt- and Mucosa-Associated Core Microbiotas in Humans and Their Alteration in Colon Cancer Patients. MBio 10. https://doi.org/10.1128/mBio.01315-19

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