Principal Investigators

Principal Investigators
Name: Daniel FALUSH
Unit Name: Unit of Statistical Genetics of Bacteria

BA Mathematics, University of Cambridge 1991

PhD Genetics, UCL 1998

Japan Society for Promotion of Science Postdoctoral fellow, Kyushu University 1998-2000

Wellcome Trust Career Development Fellow, University of Oxford 2003-2007

MRC CLiMB Fellow, University of Bath 2014-2019


Research Topic:

We develop new statistical genetic methods for analyzing large scale genomic and metagenomic datasets from many different organisms and systems. Our specific biological research focus is to understand the causes and consequences of genetic variation within highly recombining species such as Helicobacter pylori and Vibrio parahaemolyticus from historical, functional, medical, ecological and evolutionary perspectives.

Team Members:

Daniel FALUSH: Principal Investigator

Hongjin WU: Programmer

Wenxuan  XU: Research Assistant

Bin CHAO: Research Assistant

Roberto TORRES: Postdoctoral Fellow

Elise TOURRETTE: Postdoctoral Fellow


Selected Bibliography :

1.      Epidemic clones, oceanic gene pools and eco-LD in the free living marine pathogen

Vibrio parahaemolyticus.

Molecular Biology and Evolution 2015 32 1396-1410.

Cui Y, Yang X, Didelot X, Guo C, Li D, Yan Y, Zhang Y, Yuan Y, Yang H, Wang J, Wang J, Song Y,Zhou D, Falush D*, R Yang*

2.      Genome-wide association study identifies vitamin B5 biosynthesis as a host specificity factor in Campylobacter.

PNAS 2013 110 11923-11927.

Sheppard S, Didelot X, Meric G, Torralbo A, Jolley KA, Kelley DJ, Bentley SD, Maiden MCJ, Parkhill J, Falush D.

3.      Inference of population structure using dense haplotype data.

PLoS Genetics 2012 8 e1002453.

Lawson DJ, Hellenthal G, Myers S*, Falush D*.

4.      Inference of bacterial microevolution using multilocus sequence data.

Genetics 2007 175 1251-1266.

Didelot X, Falush D.

5.      Traces of human migrations in Helicobacter pylori populations.

Science 2003 299 1582-1585.

Falush D, Wirth T, Linz B, Pritchard JK, Stephens M, Kidd M, Blaser MJ, Graham DY, Vacher S, Perez-Perez GI, Yamaoka Y, Megraud F, Otto K, Reichard U, Katzowitsch E, Wang X, Achtman M, Suerbaum S.