| Name: | Chengyuan WANG | ||
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| Unit Name: | Unit of Bacterial Transcription Regulation and Antibiotics Discovery | ||
| Education(CV): | 2021-present, Principal investigator, Institut Pasteur of Shanghai, CAS, Shanghai, China
2017-2021, Postdoctoral fellow, Waksman Institute of Microbiology, Rutgers University, NJ, USA |
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| Email: | cywang@ips.ac.cn | ||
| Research Topic: |
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Transcription is the first and the most-regulated step of gene expression, by which RNA polymerase (RNAP) copies genetic information from DNA to RNA. It is fundamentally important to understand the structure, function, and regulation of the transcription machinery--RNAP. RNAPs are well conserved across bacterial species but are less conserved between bacteria and human. Therefore, bacterial RNAPs are promising drug target for antibiotic discovery. Our lab focusses on the molecular mechanism of transcription and transcription regulation, especially the mechanism of transcription and translation coupling. We also develop new antibiotics targeting different pathogenic bacterial RNAP. We employ multiple approaches in Structure biology (X-ray crystallography and cryo-EM), Biochemistry, Enzymology, Microbiology, and Bioinformatics.
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| Team Members: |
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| Positions available |
| Selected Bibliography : |
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(#co-first author) 1. Wang, C.Y.#, Molodtsov V.#, Firlar E., Kaelber J.T., Blaha G., Su M., & Ebright R. H. (2020). "Structural basis of transcription-translation coupling." Science 369(6509): 1359-1365. 2. Wang, C.Y.#, Li, J.#, Ma M., Zhu L., Lin W., & Zhang P. (2020). " Structural and biochemical insights into two BAHD acyltransferases (AtSHT and AtSDT) involved in phenolamide biosynthesis", Front. Plant. Sci. doi: 10.3389/fpls.2020.610118 3. Wang, H., Wang, C.Y., Fan, W., Yang, J., Appelhagen, I., Wu, Y., & Zhang, P. (2018). A novel glycosyltransferase catalyses the transfer of glucose to glucosylated anthocyanins in purple sweet potato. J Exp Bot. doi:10.1093/jxb/ery305 4. Li, J.#, Wang, C.Y.#, Yang, G., Sun, Z., Guo, H., Shao, K., Zhang, P. (2017). Molecular mechanism of environmental d-xylose perception by a XylFII-LytS complex in bacteria. Proc Natl Acad Sci, 114(31), 8235-8240. doi:10.1073/pnas.1620183114 5. Zhou, F.#, Wang, C.Y.#, Gutensohn, M.#, Jiang, L., Zhang, P., Zhang, D., & Lu, S. (2017). A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice. Proc Natl Acad Sci, 114(26), 6866-6871. doi:10.1073/pnas.1705689114 |
